Department of Medical Chemistry, Medical University of Białystok, ul. Mickiewicza 2a, 15-222 Białystok, Poland.
Int J Mol Sci. 2024 Oct 31;25(21):11704. doi: 10.3390/ijms252111704.
Gastrointestinal cancers are still the leading cause of death worldwide. This is related, among other things, to the non-specific symptoms, especially in the initial stages, and also to the limited possibilities for treatment. Therefore, research is still being conducted to improve the detection of this type of cancer and increase the effectiveness of therapy. The potential application of natural compounds in cancer management deserves special attention. In the group of such products, there are polyphenolic compounds that reveal, e.g., anti-oxidative, anti-carcinogenic, anti-inflammatory, anti-diabetic, and neuroprotective properties. One of these polyphenols is rosmarinic acid, commonly found in plants such as the Boraginaceae and Nepetoideae subfamilies of the Lamiaceae (mint) family. A number of studies have considered the positive effects of rosmarinic acid in the treatment of many cancers, including gastrointestinal ones such as oral, stomach, pancreas, colon, and liver cancers. The main aim of this paper was to summarize the mechanisms of action of rosmarinic acid in gastrointestinal cancers.
胃肠道癌症仍然是全球主要的死亡原因。这与非特异性症状有关，尤其是在疾病早期阶段，也与治疗方法有限有关。因此，仍在进行研究以提高对这类癌症的检测能力并提高治疗效果。天然化合物在癌症管理中的潜在应用值得特别关注。在这类产品中，有一类多酚化合物，具有抗氧化、抗癌、抗炎、抗糖尿病和神经保护等特性。其中一种多酚是迷迭香酸，它通常存在于唇形科的紫草科和荆芥科的亚科植物中。许多研究都考虑了迷迭香酸在治疗多种癌症（包括胃肠道癌症，如口腔癌、胃癌、胰腺癌、结肠癌和肝癌）中的积极作用。本文的主要目的是总结迷迭香酸在胃肠道癌症中的作用机制。
