2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Vasilissis Sofias 76, 11528 Athens, Greece.
Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, 11527 Athens, Greece.
Int J Mol Sci. 2024 Oct 31;25(21):11703. doi: 10.3390/ijms252111703.
Gynecological cancer is a term referring to malignancies that typically involve ovarian, cervical, uterine, vaginal, and vulvar cancer. Combined, these cancers represent major causes of morbidity and mortality in women with a heavy socioeconomic impact. MiRNAs are small non-coding RNAs that are intensively studied in the field of cancer and changes in them have been linked to a variety of processes involved in cancer that range from tumorigenesis to prognosis and metastatic potential. This review aims to summarize the existing literature that has linked miRNAs with each of the female malignancies as potential biomarkers in diagnosis (circulating miRNAs), in tumor histology and prognosis (as tissue biomarkers), and for local (lymph node) and distant metastatic disease.
妇科癌症是一个术语，指的是通常涉及卵巢癌、宫颈癌、子宫癌、阴道癌和外阴癌的恶性肿瘤。这些癌症加在一起是导致女性发病率和死亡率的主要原因，对社会经济有重大影响。miRNA 是一种小型非编码 RNA，在癌症领域受到广泛研究，其变化与癌症涉及的多种过程有关，从肿瘤发生到预后和转移潜能。本综述旨在总结将 miRNA 与女性恶性肿瘤中的每一种联系起来的现有文献，作为诊断（循环 miRNA）、肿瘤组织学和预后（作为组织生物标志物）以及局部（淋巴结）和远处转移疾病的潜在生物标志物。
