Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Biological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of Korea.
Int J Mol Sci. 2024 Oct 31;25(21):11713. doi: 10.3390/ijms252111713.
Cancer is a deadly disease caused by cells that deviate from the normal differentiation and proliferation behaviors and continue to multiply. There is still no definitive cure, and many side effects occur even after treatment. However, apoptosis, one of the programs imprinted on cells, is becoming an important concept in controlling cancer. Flavonoids are polyphenolic compounds found in plants, are naturally bioactive compounds, have been studied for their anticancer effects, and have fewer side effects than chemical treatments. Isoflavones are phytoestrogens belonging to the flavonoid family, and this review discusses in depth the potential anticancer effects of prunetin, one of the many flavonoid families, via the apoptotic mechanism. In addition, a glycoside called prunetin glucoside has been investigated for its anticancer effects through apoptotic mechanisms. The primary intention of this review is to identify the effects of prunetin and its glycoside, prunetin glucoside, on cell death signaling pathways in various cancers to enhance the potential anticancer effects of these natural compounds.
癌症是一种由细胞偏离正常分化和增殖行为并持续增殖引起的致命疾病。目前仍然没有明确的治愈方法，即使经过治疗，也会产生许多副作用。然而，细胞中存在的一种程序性细胞死亡机制——凋亡，正在成为控制癌症的一个重要概念。类黄酮是植物中发现的多酚化合物，是天然的生物活性化合物，因其抗癌作用而受到研究，并且比化学治疗的副作用更少。异黄酮属于黄酮类家族的植物雌激素，本综述深入探讨了作为众多黄酮类家族之一的樱黄素通过凋亡机制发挥潜在抗癌作用的机制。此外，一种名为樱黄素糖苷的糖苷也通过凋亡机制被研究其抗癌作用。本综述的主要目的是确定樱黄素及其糖苷樱黄素糖苷对各种癌症中细胞死亡信号通路的影响，以增强这些天然化合物的潜在抗癌作用。
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