School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam 690525, Kerala, India.
Department of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, Karnataka, India.
Int J Mol Sci. 2024 Nov 2;25(21):11801. doi: 10.3390/ijms252111801.
Tuberculosis caused by the obligate intracellular pathogen, , is one among the prime causes of death worldwide. An urgent remedy against tuberculosis is of paramount importance in the current scenario. However, the complex nature of this appalling disease contributes to the limitations of existing medications. The quest for better treatment approaches is driving the research in the field of host epigenomics forward in context with tuberculosis. The interplay between various host epigenetic factors and the pathogen is under investigation. A comprehensive understanding of how orchestrates such epigenetic factors and favors its survival within the host is in increasing demand. The modifications beneficial to the pathogen are reversible and possess the potential to be better targets for various therapeutic approaches. The mechanisms, including histone modifications, DNA methylation, and miRNA modification, are being explored for their impact on pathogenesis. In this article, we are deciphering the role of mycobacterial epigenetic regulators on various strategies like cytokine expression, macrophage polarization, autophagy, and apoptosis, along with a glimpse of the potential of host-directed therapies.
结核分枝杆菌是一种专性细胞内病原体，是全球主要死亡原因之一。在当前情况下，迫切需要一种针对结核病的治疗方法。然而，这种可怕疾病的复杂性导致了现有药物的局限性。为了寻找更好的治疗方法，宿主表观基因组学领域的研究正在向前推进。目前正在研究各种宿主表观遗传因子与病原体之间的相互作用。越来越需要深入了解结核分枝杆菌如何协调这些表观遗传因子并有利于其在宿主内的存活。对病原体有益的修饰是可逆的，有可能成为各种治疗方法的更好靶点。包括组蛋白修饰、DNA 甲基化和 miRNA 修饰在内的机制正在被探索，以了解它们对发病机制的影响。在本文中，我们正在破译分枝杆菌表观遗传调节剂在细胞因子表达、巨噬细胞极化、自噬和细胞凋亡等各种策略中的作用，同时也探讨了宿主定向治疗的潜力。
