Innovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama 252-8583, Kanagawa, Japan.
Food Research & Development Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama 252-8583, Kanagawa, Japan.
Nutrients. 2024 Oct 22;16(21):3580. doi: 10.3390/nu16213580.
Probiotics, particularly those native to the gut microbiota, have a profound influence on the gut environment. In this study, we conducted a randomized placebo-controlled, double-blind, parallel-group comparison trial to investigate the effects of BB536 ( BB536) on the fecal microbiota and metabolite compositions in healthy individuals. We compared the effects of fermented milk produced solely with and (placebo group) and fermented milk supplemented with BB536 (BY group). Our findings revealed a significantly greater relative abundance of in the BY group than in the placebo group by the 3rd day, a trend that persisted until the end of the trial on the 17th day. Additionally, the BY group presented significantly increased concentrations of tryptophan (Trp), Indole-3-lactic acid, and Indole-3-aldehyde on the 17th day. A significant positive correlation was observed between the relative abundance of and the number of viable BB536 bacteria in the feces. The concentrations of Trp and Indole-3-acetic acid were also significantly correlated with the number of viable BB536 bacteria in the feces. Our results suggest that BB536 intake can modulate the gut microbiota and metabolite profiles, which are general indicators for monitoring the gut environment, potentially conferring health benefits to the host.
益生菌，特别是那些天然存在于肠道微生物群中的益生菌，对肠道环境有深远的影响。在这项研究中，我们进行了一项随机、安慰剂对照、双盲、平行组比较试验，旨在研究 BB536（BB536）对健康个体粪便微生物群和代谢产物组成的影响。我们比较了仅使用 和 （安慰剂组）和添加 BB536 的发酵乳（BY 组）生产的发酵乳的效果。我们的研究结果表明，BY 组中 的相对丰度在第 3 天明显高于安慰剂组，这一趋势一直持续到第 17 天试验结束。此外，BY 组在第 17 天表现出色氨酸（Trp）、吲哚-3-乳酸和吲哚-3-乙醛浓度显著增加。在粪便中， 的相对丰度与活的 BB536 细菌数量之间存在显著的正相关。Trp 和吲哚-3-乙酸的浓度也与粪便中活的 BB536 细菌数量显著相关。我们的研究结果表明，摄入 BB536 可以调节肠道微生物群和代谢产物谱，这些都是监测肠道环境的一般指标，可能对宿主健康有益。
