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镁和钾补充剂降低一般血压正常人群的收缩压：最佳剂量和治疗时长的系统评价和亚组荟萃分析。

Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length.

机构信息

Department of Clinical Sciences, Florida State University College of Medicine, Tallahassee, FL 32304, USA.

Florida State University Internal Medicine Residency at Sarasota Memorial Hospital, Sarasota, FL 34239, USA.

出版信息

Nutrients. 2024 Oct 24;16(21):3617. doi: 10.3390/nu16213617.

DOI:10.3390/nu16213617
PMID:39519450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11547496/
Abstract

BACKGROUND/OBJECTIVES: Studies have shown that consistent reductions of 2 mm Hg in systolic blood pressure (SBP) for the general normotensive population can result in significant decreases in mortality from heart disease and stroke. The purpose of this meta-analysis was to determine the optimal dose and duration of treatment for magnesium and potassium supplementation, having previously discovered that both reduce SBP by -2.79 and -2.10 mm Hg, respectively.

METHODS

Placebo-controlled, randomized clinical trials examining the effects of magnesium and potassium supplementation on SBP were identified. Pairwise meta-analyses with subgroups for dosage and treatment duration were run.

RESULTS

Magnesium at dosages of ≤360 mg/day and durations greater than 3 months reduced SBP by -3.03 and -4.31 mm Hg, respectively. Potassium at dosages of ≤60 mmol/day and durations greater than 1 month reduced SBP by -2.34 and -2.80 mm Hg, respectively.

CONCLUSIONS

Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations. Future studies are needed to validate these findings and provide tailored recommendations. These studies could investigate varying dosages over long-term follow-up to provide robust data on optimal dosages and treatment durations, as our findings were limited due to reliance on previously published trials.

摘要

背景/目的：研究表明，对于一般正常血压人群，收缩压（SBP）持续降低 2mmHg 可显著降低心脏病和中风的死亡率。本荟萃分析的目的是确定镁和钾补充的最佳剂量和治疗持续时间，因为我们之前发现两者分别使 SBP 降低-2.79 和-2.10mmHg。

方法

确定了安慰剂对照、随机临床试验，以研究镁和钾补充对 SBP 的影响。进行了剂量和治疗持续时间亚组的成对荟萃分析。

结果

镁的剂量≤360mg/天且治疗时间超过 3 个月时，SBP 分别降低-3.03 和-4.31mmHg。钾的剂量≤60mmol/天且治疗时间超过 1 个月时，SBP 分别降低-2.34 和-2.80mmHg。

结论

这两种补充剂在较低剂量和更长的治疗时间内对一般人群的 SBP 降低幅度更大。需要进一步的研究来验证这些发现并提供针对性的建议。这些研究可以在长期随访中研究不同的剂量，以提供最佳剂量和治疗持续时间的可靠数据，因为我们的发现受到先前发表的试验的限制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/f452be79d750/nutrients-16-03617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/71b1b539c9b1/nutrients-16-03617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/760401916f42/nutrients-16-03617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/3f27248a1601/nutrients-16-03617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/eb27dad5db48/nutrients-16-03617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/f452be79d750/nutrients-16-03617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/71b1b539c9b1/nutrients-16-03617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/760401916f42/nutrients-16-03617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/3f27248a1601/nutrients-16-03617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/eb27dad5db48/nutrients-16-03617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e50/11547496/f452be79d750/nutrients-16-03617-g005.jpg

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