Gastrointestinal Research Group, Inflammation Research Network, Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Nutrients. 2024 Oct 25;16(21):3620. doi: 10.3390/nu16213620.
Dietary intervention is a subject of growing interest in the management of inflammatory bowel disease (IBD), as new incident cases across the globe are rapidly rising, suggesting environmental factors as contributing elements. Dietary components and micronutrients have been associated with IBD pathogenesis or reductions in disease severity. Selenium, a diet-derived essential micronutrient that is important for proper immune system function, has received limited attention in the context of IBD. Selenium deficiency is a common finding in patients with IBD, but few clinical trials have been published to address the consequences of this deficiency. Here, we review the physiological and immunological roles of selenium and its putative role in IBD, and draw attention to knowledge gaps and unresolved issues, with the goal of stimulating more research on selenium in IBD.
饮食干预是炎症性肠病（IBD）管理中日益受到关注的一个课题，因为全球新发病例迅速增加，提示环境因素是致病因素之一。饮食成分和微量营养素与 IBD 的发病机制或疾病严重程度的降低有关。硒是一种饮食中必需的微量营养素，对免疫系统的正常功能很重要，但在 IBD 方面的研究却很有限。IBD 患者中硒缺乏很常见，但很少有临床试验来解决这种缺乏的后果。在这里，我们回顾了硒的生理和免疫学作用及其在 IBD 中的可能作用，并提请注意知识空白和未解决的问题，旨在激发更多关于 IBD 中硒的研究。
