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子痫前期及其对早产儿生长和身体成分的未来影响。

Preeclampsia and Future Implications on Growth and Body Composition in Preterm Infants.

机构信息

Department of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care Medicine and Neuropaediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Department of Obstetrics and Gynaecology, Medical University of Vienna, 1090 Vienna, Austria.

出版信息

Nutrients. 2024 Oct 25;16(21):3627. doi: 10.3390/nu16213627.

DOI:10.3390/nu16213627
PMID:39519460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11547833/
Abstract

BACKGROUND

Preeclampsia is associated with intrauterine growth restriction (IUGR), which can lead to impaired postnatal growth and neurodevelopment in preterm infants. Preeclampsia can also occur without IUGR and its impact on postnatal nutrition, growth, and body composition remains not fully investigated to the best of our knowledge.

METHODS

This study included infants born before 37 weeks of gestation who underwent air displacement plethysmography to measure body composition (fat-free mass [FFM] and fat mass [FM]) at term-equivalent age. We compared infants born to mothers with preeclampsia and IUGR (PE-IUGR group) and preeclampsia without IUGR (PE-non-IUGR group) to those born to mothers without preeclampsia (control group).

RESULTS

In total, 291 infants were enrolled (control: = 227; PE-non-IUGR: = 43; PE-IUGR: = 21). FFM was significantly lower in the PE-IUGR (mean differences -231 g (IQR: (-373, -88); < 0.001)) and PE-non-IUGR groups (mean differences -260 g (IQR: (-372, -149); < 0.001)) in comparison to the control group. FM was not significantly different between the three groups.

CONCLUSIONS

This study indicates that infants of preeclamptic mothers, even without IUGR, had significantly lower FFM at term-equivalent age compared to the control group. Further research is necessary to determine if these variations can be modified.

摘要

背景

子痫前期与宫内生长受限（IUGR）有关，这可能导致早产儿出生后生长和神经发育受损。子痫前期也可以在没有 IUGR 的情况下发生，但其对早产儿出生后营养、生长和身体成分的影响我们知之甚少。

方法

本研究纳入了在 37 孕周前出生的婴儿，他们在胎龄相当时接受空气置换体积描记术测量身体成分（去脂体重[FFM]和脂肪量[FM]）。我们比较了母亲患有子痫前期和 IUGR（PE-IUGR 组）、母亲患有子痫前期但无 IUGR（PE-non-IUGR 组）与母亲无子痫前期（对照组）的婴儿。

结果

共纳入 291 名婴儿（对照组： = 227；PE-non-IUGR 组： = 43；PE-IUGR 组： = 21）。与对照组相比，PE-IUGR 组（平均差异 -231 克（IQR：（-373，-88）；< 0.001））和 PE-non-IUGR 组（平均差异 -260 克（IQR：（-372，-149）；< 0.001））的 FFM 明显较低。三组间 FM 无显著差异。

结论

本研究表明，即使没有 IUGR，子痫前期母亲的婴儿在胎龄相当时的 FFM 明显低于对照组。需要进一步研究以确定这些差异是否可以改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33d/11547833/a41b3d4f22c7/nutrients-16-03627-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33d/11547833/a41b3d4f22c7/nutrients-16-03627-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33d/11547833/a41b3d4f22c7/nutrients-16-03627-g001.jpg

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Hypertensive disorders of pregnancy.妊娠高血压疾病。
BMJ. 2023 Jun 30;381:e071653. doi: 10.1136/bmj-2022-071653.
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Classification and Special Nutritional Needs of SGA Infants and Neonates of Multiple Pregnancies.小于胎龄儿和双胎妊娠新生儿的分类及特殊营养需求。
Nutrients. 2023 Jun 13;15(12):2736. doi: 10.3390/nu15122736.
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Ultrasound Obstet Gynecol. 2023 Dec;62(6):788-795. doi: 10.1002/uog.26290.
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Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring.子痫前期影响母亲及其后代的脂质代谢和高密度脂蛋白功能。
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