Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Ahram Canadian University, Giza 12581, Egypt.
Nutrients. 2024 Oct 25;16(21):3633. doi: 10.3390/nu16213633.
BACKGROUND/OBJECTIVE: Intestinal fibrosis, a prominent consequence of inflammatory bowel disease (IBD), presents considerable difficulty owing to the absence of licensed antifibrotic therapies. This review assesses the therapeutic potential of phytochemicals as alternate methods for controlling intestinal fibrosis. Phytochemicals, bioactive molecules originating from plants, exhibit potential antifibrotic, anti-inflammatory, and antioxidant activities, targeting pathways associated with inflammation and fibrosis. Compounds such as Asperuloside, Berberine, and olive phenols have demonstrated potential in preclinical models by regulating critical signaling pathways, including TGF-β/Smad and NFκB, which are integral to advancing fibrosis.
The main findings suggest that these phytochemicals significantly reduce fibrotic markers, collagen deposition, and inflammation in various experimental models of IBD. These phytochemicals may function as supplementary medicines to standard treatments, perhaps enhancing patient outcomes while mitigating the adverse effects of prolonged immunosuppressive usage. Nonetheless, additional clinical trials are necessary to validate their safety, effectiveness, and bioavailability in human subjects.
Therefore, investigating phytochemicals may lead to crucial advances in the formulation of innovative treatment approaches for fibrosis associated with IBD, offering a promising avenue for future therapeutic development.
背景/目的：肠纤维化是炎症性肠病（IBD）的一个突出后果，由于缺乏许可的抗纤维化疗法，因此存在相当大的困难。本综述评估了植物化学物质作为控制肠纤维化的替代方法的治疗潜力。植物化学物质是源自植物的生物活性分子，具有潜在的抗纤维化、抗炎和抗氧化活性，针对与炎症和纤维化相关的途径。阿朴斯罗甙、小檗碱和橄榄油酚等化合物通过调节 TGF-β/Smad 和 NFκB 等关键信号通路，在 IBD 的各种实验模型中显示出潜在的作用，这些通路是纤维化进展的关键。
主要发现表明，这些植物化学物质可显著降低 IBD 各种实验模型中的纤维化标志物、胶原蛋白沉积和炎症。这些植物化学物质可以作为标准治疗的辅助药物，可能会改善患者的预后，同时减轻长期使用免疫抑制剂的不良反应。然而，仍需要更多的临床试验来验证它们在人体中的安全性、有效性和生物利用度。
因此，研究植物化学物质可能会为 IBD 相关纤维化的创新治疗方法的制定带来重要进展，为未来的治疗开发提供有前途的途径。
