Health Department, Universidad Iberoamericana, Mexico City 01219, Mexico.
Master in Applied Nutriology Program, Universidad Iberoamericana, Mexico City 01219, Mexico.
Nutrients. 2024 Oct 29;16(21):3683. doi: 10.3390/nu16213683.
Dietary fats influence gene expression and several metabolic pathways. Therefore, it is crucial to study the role of personal genotypes in the interaction between fat consumption and cardiometabolic markers. This research aimed to determine the interaction of the rs708272 polymorphism of and the fatty acid intake with changes in the HOMA-IR in adults living with overweight or obesity. The current study was a secondary analysis of an 8-week controlled clinical trial. The final sample for this analysis comprised 78 Mexican adults with the Cholesteryl Ester Transfer Protein ( rs708272 polymorphism who followed a dietary intervention. Using an interaction analysis, we evaluated the fatty acid intake and the genotypes of rs708272, with changes in blood glucose, insulin, and the HOMA-IR from baseline to endpoint. Our findings suggest a significant interaction between the trans fatty acid intake and the GG genotype with changes in glucose ( = 0.024), insulin ( = 0.004), and the HOMA-IR ( = 0.002). The higher the consumption of trans fatty acids, the less these markers of glucose metabolism were reduced. carriers of the GG genotype may benefit from limiting dietary trans fatty acid intake, as there was no reduction in plasma glucose and insulin despite a hypocaloric dietary intervention in adults with overweight and obesity.
膳食脂肪会影响基因表达和多种代谢途径。因此，研究个人基因型在脂肪摄入与心血管代谢标志物相互作用中的作用至关重要。本研究旨在确定载脂蛋白 E(rs708272 多态性)与脂肪酸摄入与超重或肥胖成年人的 HOMA-IR 变化之间的相互作用。本研究是对为期 8 周的对照临床试验的二次分析。本分析的最终样本包括 78 名接受饮食干预的墨西哥成年人，他们携带胆固醇酯转移蛋白(rs708272 多态性)。通过交互分析，我们评估了脂肪酸摄入和 rs708272 基因型与血糖、胰岛素和 HOMA-IR 从基线到终点的变化之间的关系。我们的研究结果表明，反式脂肪酸摄入与 GG 基因型与血糖变化之间存在显著的相互作用（=0.024），胰岛素（=0.004）和 HOMA-IR（=0.002）。反式脂肪酸摄入越高，葡萄糖代谢标志物的降低幅度就越小。GG 基因型携带者可能受益于限制饮食中的反式脂肪酸摄入，因为在超重和肥胖成年人进行低热量饮食干预时，尽管摄入了低热量饮食，但血糖和胰岛素并没有降低。
