Department of Clinical Nutrition, Fujita Health University, Toyoake 470-1192, Japan.
Department of Dentistry and Oral-Maxillofacial Surgery, Fujita Health University, Toyoake 470-1192, Japan.
Nutrients. 2024 Oct 30;16(21):3715. doi: 10.3390/nu16213715.
BACKGROUND/OBJECTIVES: The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B (B) levels).
During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical ( (HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B levels in 92 individuals (M:67, F:25).
Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3, = 0.04). Independent of physical or chemical digestion parameters, serum PAB and B levels were significantly associated with protein and B intake, respectively.
Oral antacid use may decrease serum PAB levels, indicating protein synthesis.
背景/目的：本研究旨在探讨物理和化学消化与营养标志物（血清白蛋白（ALB）、前白蛋白（PAB）和维生素 B（B）水平）之间的关系。
在藤田保健卫生大学进行详细体检时，我们检查了 92 名个体（男性 67 人，女性 25 人）的物理（咬合力、咀嚼性能和吞咽能力（通过 10 项饮食评估工具，EAT-10））和化学（（HP）根除史、HP 抗体水平和口服抗酸剂（质子泵抑制剂）使用）消化参数与血清 ALB、PAB 和 B 水平的相关性。
48%的参与者年龄大于 65 岁，19%的参与者咬合力下降，3.2%的参与者咀嚼力下降，3.2%的参与者吞咽功能下降，24%的参与者有 HP 根除史，23%的参与者 HP 抗体阳性，16%的参与者服用口服抗酸药。此外，14%和 11%的患者血清 ALB 和 PAB 水平分别较低，14%的患者 B 族维生素缺乏。经年龄、性别、体重指数和 C 反应蛋白水平调整的多变量分析显示，物理消化参数与血清 PAB、ALB 或 B 水平之间无显著相关性。另一方面，口服抗酸药的使用与 PAB 水平呈显著负相关（β = -3.3， = 0.04）。独立于物理或化学消化参数，血清 PAB 和 B 水平与蛋白质和 B 族维生素的摄入呈显著相关。
口服抗酸药的使用可能会降低血清 PAB 水平，提示蛋白质合成。
