Department of Orthopaedics and Traumatology, Dr L. Blazek Multi-Specialty Hospital, 88-100 Inowroclaw, Poland.
Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
Nutrients. 2024 Oct 31;16(21):3735. doi: 10.3390/nu16213735.
Numerous studies have shown that vitamin D may play an important role in modulating the inflammatory process. This study aimed to evaluate the effect of vitamin D supplementation on inflammatory markers in patients with orthopedic disorders and obesity. Thirty-three obese subjects were included in the study and were divided into two groups based on their medical condition: acute orthopedic diseases and chronic orthopedic diseases. Inclusion criteria for the research included age 18-75 years, BMI > 30 kg/m, vitamin D deficiency, and no previous vitamin D supplementation. Samples were collected before and after 3 months of 4000 IU/day vitamin D supplementation. The study used enzyme-linked immunosorbent assay (ELISA) and measured serum levels of markers such as chitinase-3-like protein 1 (YKL-40), interleukin 6 (IL-6), interleukin 17 (IL-17), tumor necrosis factor (TNF-α), and adiponectin. After 3 months of vitamin D supplementation, a statistically significant increase in vitamin D and IL-17 levels was observed in the group with acute orthopedic diseases. Similarly, after supplementation, a statistically significant increase in vitamin D, IL-6 and TNF-α levels was observed in the group with chronic orthopedic diseases. Moreover, after vitamin D supplementation, statistically significantly higher adiponectin levels were observed in the chronic orthopedic group than in the acute orthopedic group. Despite high-dose vitamin D supplementation, inflammatory markers increased in acute and chronic orthopedic conditions. Based on our study, vitamin D does not reduce inflammation in patients with orthopedic conditions and obesity.
许多研究表明，维生素 D 可能在调节炎症过程中发挥重要作用。本研究旨在评估维生素 D 补充对骨科疾病和肥胖患者炎症标志物的影响。研究纳入了 33 名肥胖患者，并根据其疾病状况分为两组：急性骨科疾病和慢性骨科疾病。研究的纳入标准包括年龄 18-75 岁、BMI>30kg/m、维生素 D 缺乏和未进行过维生素 D 补充。在 4000IU/天维生素 D 补充 3 个月前后采集样本。本研究采用酶联免疫吸附试验（ELISA），测量了血清标志物如壳聚糖酶-3 样蛋白 1（YKL-40）、白细胞介素 6（IL-6）、白细胞介素 17（IL-17）、肿瘤坏死因子（TNF-α）和脂联素的水平。在接受 3 个月的维生素 D 补充后，急性骨科疾病组的维生素 D 和 IL-17 水平显著增加。同样，在补充后，慢性骨科疾病组的维生素 D、IL-6 和 TNF-α水平也显著增加。此外，在补充维生素 D 后，慢性骨科疾病组的脂联素水平显著高于急性骨科疾病组。尽管进行了高剂量的维生素 D 补充，但在急性和慢性骨科疾病中，炎症标志物仍有所增加。根据我们的研究，维生素 D 不能减轻骨科疾病和肥胖患者的炎症。
