Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy and Food Sciences, Universitat de València, Av. Vicent Andrés Estelles s/n, 46100 Burjassot, València, Spain.
Food and Environmental Safety Research Group of the Universitat de València (SAMA-UV), Desertification Research Centre (CIDE) CSIC-GV-UV, CV-315 Km. 10, 7, 46113 Moncada, València, Spain.
Nutrients. 2024 Oct 31;16(21):3740. doi: 10.3390/nu16213740.
Every year the global incidence of obesity increases considerably and among the factors that favor it is bisphenol A (BPA), an endocrine disruptor widely used in plastics and omnipresent in many everyday objects.
A total of 19 studies published between 2018 and 2023 that addressed the relationship between BPA exposure and obesity were included in this review in order to better understand its behavior and mechanisms of action.
The studies reviewed conclude that BPA is an obesogen that alters the function of hormonal receptors, promotes metabolic syndrome, affects certain genes, etc., leading to a greater risk of developing obesity. With important emphasis on the ability to cause epigenetic changes, thus transmitting the effects to offspring when exposure has occurred during critical stages of development such as during gestation or the perinatal period.
There is sufficient evidence to show that BPA is a risk factor in the development of obesity. Even so, further research is necessary to exhaustively understand the causal relationship between the two in order to develop prevention measures and avoid possible future adverse effects.
全球肥胖症的发病率每年都在大幅增加，而其中一个促进肥胖的因素就是双酚 A（BPA），这是一种广泛应用于塑料的内分泌干扰物，存在于许多日常用品中。
本综述纳入了 2018 年至 2023 年期间发表的总共 19 项研究，这些研究探讨了 BPA 暴露与肥胖之间的关系，以更好地了解其行为和作用机制。
综述中的研究得出结论，BPA 是一种致肥胖物，它改变了激素受体的功能，促进了代谢综合征，影响了某些基因等，从而增加了肥胖的风险。特别强调了其能够引起表观遗传变化的能力，因此当暴露发生在发育的关键阶段（如妊娠期或围产期）时，会将这些影响传递给后代。
有充分的证据表明 BPA 是肥胖症发展的一个风险因素。即便如此，仍需要进一步研究以详尽了解两者之间的因果关系，从而制定预防措施并避免可能的未来不良影响。
