Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China.
Institute of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People's Republic of China.
Int J Nanomedicine. 2024 Nov 5;19:11293-11303. doi: 10.2147/IJN.S485441. eCollection 2024.
The incidence of chronic wounds is steadily increasing each year, yet conventional treatments for chronic wounds yield unsatisfactory results. The delayed healing of chronic wounds significantly affects patient quality of life, placing a heavy burden on patients, their families, and the healthcare system. Therefore, there is an urgent need to find new treatment methods for chronic wounds. Plant-derived exosome-like nanovesicles (PELNs) may be able to accelerate chronic wound healing. PELNs possess advantages such as good accessibility (due in part to high isolation yields), low immunogenicity, and good stability. Currently, there are limited reports regarding the role of PELNs in chronic wound healing and their associated mechanisms, highlighting their novelty and the necessity for further research. This review aims to provide an overview of PELNs, discussing isolation methods, composition, and their mechanisms of action in chronic wound healing. Finally, we summarize future opportunities and challenges related to the use of PELNs for the treatment of chronic wounds, and offer some new insights and solutions.
慢性创面的发病率逐年稳步上升，但慢性创面的传统治疗方法疗效并不理想。慢性创面的愈合延迟显著影响患者的生活质量，给患者、患者家庭和医疗体系带来沉重负担。因此，迫切需要寻找慢性创面的新治疗方法。植物来源的外泌体样纳米囊泡（PELN）可能能够加速慢性创面愈合。PELN 具有良好的可及性（部分原因是高分离产量）、低免疫原性和良好的稳定性等优点。目前，关于 PELN 在慢性创面愈合中的作用及其相关机制的报道有限，这突出了其新颖性和进一步研究的必要性。本综述旨在概述 PELN，讨论其分离方法、组成以及在慢性创面愈合中的作用机制。最后，我们总结了使用 PELN 治疗慢性创面的未来机遇和挑战，并提出了一些新的见解和解决方案。
