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偏远农村患者恶性中央气道阻塞的外照射放疗:病例报告

External Beam Radiotherapy for Malignant Central Airway Obstruction in a Remote Rural Patient: A Case Study.

作者信息

Collins Eoin, Mitra Druva, Carruthers Scott

机构信息

Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, SA, Australia.

出版信息

Case Rep Oncol. 2024 Nov 12;17(1):1301-1308. doi: 10.1159/000542104. eCollection 2024 Jan-Dec.

Abstract

INTRODUCTION

Malignant central airway obstruction (MCAO) is a challenging therapeutic scenario, caused by tumour burden which limits airflow within the large airways. Squamous cell carcinoma (SCC) of the lung accounts for 50% of MCAO seen in the setting of non-small cell lung cancer. Here, we present the challenging case of a 63-year-old Indigenous Australian Female rom a remote rural community with background history of metastatic SCC of presumed pulmonary origin, who presented with a 1-week history of dyspnoea, stridor, and hoarse voice.

CASE PRESENTATION

A CT chest and neck demonstrated a superior mediastinal mass compressing the trachea to a narrowest diameter of 3 mm. The patient was stabilised in her local health centre, then transferred to our tertiary care facility for further evaluation and management. This stenotic lesion was not amenable to bronchoscopic or surgical intervention but was instead treated successfully with a short course of external beam radiotherapy, to total dose of 25Gy delivered over 10 fractions. The patient had almost complete resolution of respiratory symptoms with no significant radiotherapy related toxicity.

CONCLUSION

Here, we discuss a challenging case of MCAO in a remote rural Australian patient and demonstrate the utility of external beam radiotherapy in this setting. We also discuss aspects of cancer related healthcare disparities which exist for Indigenous Australians. In doing so, we wish to highlight the need for improved cancer healthcare for such communities.

摘要

引言

恶性中央气道阻塞(MCAO)是一种具有挑战性的治疗情况,由肿瘤负荷导致大气道内气流受限引起。肺癌中的鳞状细胞癌(SCC)占非小细胞肺癌背景下所见MCAO的50%。在此,我们介绍一例具有挑战性的病例,一名63岁的澳大利亚原住民女性,来自偏远农村社区,有推测为肺源性转移性SCC的背景病史,出现了1周的呼吸困难、喘鸣和声音嘶哑症状。

病例介绍

胸部和颈部CT显示上纵隔肿块,将气管压迫至最窄直径3毫米。患者在当地卫生中心病情稳定,随后转至我们的三级医疗设施进行进一步评估和管理。这种狭窄病变不适合支气管镜或手术干预,而是通过短程外照射放疗成功治疗,总剂量25Gy,分10次给予。患者的呼吸道症状几乎完全缓解,且无明显的放疗相关毒性。

结论

在此,我们讨论了一名澳大利亚偏远农村患者的具有挑战性的MCAO病例,并展示了外照射放疗在此情况下的效用。我们还讨论了澳大利亚原住民存在的癌症相关医疗保健差异方面的问题。通过这样做,我们希望强调改善此类社区癌症医疗保健的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e69/11556858/2fb5a18bc51e/cro-2024-0017-0001-542104_F01.jpg

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