López-Córdova J, Machuca P, Araya-Contreras T, Briceño-Montero C, Pérez-Tobar S, Faúndez Comte P, Castillo-Ruiz M, Bittner M
Laboratorio de Microbiología y Biotecnología Oral, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.
Departamento de Ciencias Químicas y Biológicas, Escuela de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago, Chile.
J Small Anim Pract. 2025 Mar;66(3):177-186. doi: 10.1111/jsap.13800. Epub 2024 Nov 13.
To determine the prevalence of uropathogens in dogs and cats with signs of urinary tract infection and to characterise their antimicrobial susceptibility.
Urine samples from canine and feline patients with clinical signs of urinary tract infection were collected between September 2015 and December 2019 in Santiago, Chile. Bacterial identification and bacterial susceptibility profile was performed through biochemical and antimicrobial susceptibility tests.
Four hundred sixty-six samples from dogs (37.7%) and 152 from cats (26.1%) showed bacterial growth. Positive samples were mainly from females (dogs: 52.8%; cats: 48.0%), with the highest infection rates in senior dogs (57.7%) and adult cats (45.4%). A single organism caused the infection in 78.2% of the cases, whereas the remaining 21.8% corresponded to a mixed infection. The most prevalent isolated pathogen in dogs and cats was Escherichia coli (42.6% and 49.7%, respectively). Staphylococcus spp. (15.6% and 14.6%), Enterococcus spp. (8.6% and 15.2%) and Proteus spp. (9.7% and 6.4%) were also commonly isolated. A total of 52.4% of Escherichia coli isolates were resistant to amoxicillin, 44.3% to amoxicillin/clavulanic acid, 40.0% to cephradine and 25.3% to ciprofloxacin. Regarding the other three uropathogens commonly isolated in this study, all of them showed a percentage of resistance to the antimicrobials analysed. In addition, 24.6% of multidrug resistance was detected in the E. coli isolates. Penicillin, cephalosporins and fluoroquinolones showed the lowest susceptibility levels.
The observed high rates of resistance to commonly prescribed antimicrobials raise concerns for public health.
确定有尿路感染症状的犬猫尿路致病菌的流行情况，并描述其抗菌药物敏感性。
2015年9月至2019年12月期间，在智利圣地亚哥收集了有尿路感染临床症状的犬猫患者的尿液样本。通过生化和抗菌药物敏感性试验进行细菌鉴定和细菌敏感性分析。
466份犬类样本（37.7%）和152份猫类样本（26.1%）显示有细菌生长。阳性样本主要来自雌性（犬：52.8%；猫：48.0%），老年犬（57.7%）和成年猫（45.4%）的感染率最高。78.2%的病例由单一病原体引起感染，其余21.8%为混合感染。犬猫中最常见的分离病原体是大肠杆菌（分别为42.6%和49.7%）。葡萄球菌属（15.6%和14.6%）、肠球菌属（8.6%和15.2%）和变形杆菌属（9.7%和6.4%）也经常被分离出来。总共52.4%的大肠杆菌分离株对阿莫西林耐药，44.3%对阿莫西林/克拉维酸耐药，40.0%对头孢拉定耐药，25.3%对环丙沙星耐药。关于本研究中另外三种常见的尿路致病菌，它们对所分析的抗菌药物均显示出一定比例的耐药性。此外，在大肠杆菌分离株中检测到24.6%的多重耐药性。青霉素、头孢菌素和氟喹诺酮类药物的敏感性最低。
观察到的对常用抗菌药物的高耐药率引起了对公共卫生的关注。
