Hidden Power: PAR4's Role in Liver Damage From Acetaminophen Overdose in Mice.
作者信息
Kendrick NaShea C, Nieman Marvin T
机构信息
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH.
出版信息
Arterioscler Thromb Vasc Biol. 2025 Jan;45(1):72-73. doi: 10.1161/ATVBAHA.124.321881. Epub 2024 Nov 14.
Abstract
摘要
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1
Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice.
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2
The domino effect triggered by the tethered ligand of the protease activated receptors.
Thromb Res. 2020 Dec;196:87-98. doi: 10.1016/j.thromres.2020.08.004. Epub 2020 Aug 4.
3
Protease-Activated Receptor PAR-4: An Inducible Switch between Thrombosis and Vascular Inflammation?
Thromb Haemost. 2017 Nov;117(11):2013-2025. doi: 10.1160/TH17-03-0219. Epub 2017 Nov 30.
4
Acetaminophen-induced Liver Injury: from Animal Models to Humans.
J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15.
5
Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.
Blood. 2015 Oct 8;126(15):1835-43. doi: 10.1182/blood-2014-09-598656. Epub 2015 Jul 15.
6
Signal transduction by protease-activated receptors.
Br J Pharmacol. 2010 May;160(2):191-203. doi: 10.1111/j.1476-5381.2010.00705.x.
7
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
Hepatology. 2007 Oct;46(4):1177-86. doi: 10.1002/hep.21779.
8
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site.
Biochemistry. 2007 Jul 24;46(29):8603-10. doi: 10.1021/bi700597p. Epub 2007 Jun 27.
9
Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells.
J Pharmacol Exp Ther. 2007 Aug;322(2):668-77. doi: 10.1124/jpet.107.121038. Epub 2007 May 9.
10
Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin.
J Biol Chem. 2000 Aug 18;275(33):25216-21. doi: 10.1074/jbc.M004589200.
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