Department of Critical Care Medicine, Shanghai Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China.
Department of Anesthesiology and Pain Center, Shanghai Changhai Hospital, Navel Medical University, Shanghai, China.
Sci Data. 2024 Nov 14;11(1):1229. doi: 10.1038/s41597-024-04078-2.
Chronic postsurgical pain (CPSP), with a high prevalence and rising epidemic of opioids crisis, is typically derived from acute postoperative pain. Our knowledge on the forming of chronic pain mostly derives from mechanistic studies of pain processing in the brain and spinal cord circuits, yet most pharmacological interventions targeting CNS came to be unhelpful in preventing CPSP. Revealing the peripheral mechanisms behind the transition from acute to chronic pain after surgery could shine a light on the novel analgesic regimens. Based on two recognized animal models in simulation of acute and chronic postsurgical pain, we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the time-course transcriptomic variation in the tissue of skin, muscle and dorsal root ganglion (DRG) in these two pain models. The aim of this study is to identify the potential origin and mechanism of the persistent postoperative pain, and further to explore effective and safer analgesic regimens for surgical patients.
慢性术后疼痛（CPSP）的患病率高，且阿片类药物危机呈上升趋势，通常源于急性术后疼痛。我们对慢性疼痛形成的认识主要来自于大脑和脊髓电路中疼痛处理的机制研究，但大多数针对中枢神经系统的药物干预措施在预防 CPSP 方面都没有帮助。揭示手术后从急性疼痛向慢性疼痛转变的外周机制可能为新的镇痛方案提供启示。基于模拟急性和慢性术后疼痛的两个公认动物模型，我们提供了下一代 RNA 测序（RNA-seq）数据集，以评估这两种疼痛模型中皮肤、肌肉和背根神经节（DRG）组织中转录组的时程变化。本研究的目的是确定持续性术后疼痛的潜在起源和机制，并进一步探索手术患者有效且更安全的镇痛方案。
