Department of Neurosurgery, the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Gansu Provincial Clinical Research Center for Neurological Diseases, the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Cell Death Dis. 2024 Nov 15;15(11):834. doi: 10.1038/s41419-024-07228-x.
Glioma is a common primary nervous system malignant tumor with poor overall cure rate and low survival rate, yet successful treatment still remains a challenge. Here, we demonstrated that amantadine (AMT) exhibits the powerful anti-glioma effect by promoting apoptosis and autophagy in vivo and in vitro. Mechanistically, amantadine induces a large amount of reactive oxygen species (ROS) accumulation in glioma cells, and then triggers apoptosis by destroying mitochondria. In addition, amantadine induces the initiation of autophagy and inhibits the fusion of autophagosome and lysosome, consequently performing an anti-glioma role. Taken together, our findings suggest that amantadine could be a promising anti-glioma drug that inhibits glioma cells by inducing apoptosis and autophagy, which may provide a novel potential treatment option for patients.
神经胶质瘤是一种常见的原发性神经系统恶性肿瘤，整体治愈率和存活率都较低，但成功治疗仍然是一个挑战。在这里，我们证明金刚烷胺（AMT）通过在体内和体外促进细胞凋亡和自噬来发挥强大的抗神经胶质瘤作用。从机制上讲，金刚烷胺会导致神经胶质瘤细胞中大量活性氧（ROS）的积累，然后通过破坏线粒体来引发细胞凋亡。此外，金刚烷胺会诱导自噬的起始，并抑制自噬体和溶酶体的融合，从而发挥抗神经胶质瘤作用。总之，我们的研究结果表明，金刚烷胺可以通过诱导细胞凋亡和自噬来抑制神经胶质瘤细胞，这可能为患者提供一种新的潜在治疗选择。
