高强度间歇训练对乳腺癌女性生活质量和化疗副作用发生率的影响。
The Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer.
机构信息
Riga Stradins University, Latvian Academy of Sport Education, Riga, Latvia.
Lithuanian Sport University, Kaunas, Lithuania.
出版信息
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241297385. doi: 10.1177/15347354241297385.
UNLABELLED
Women with breast cancer (BC) experience multiple symptoms related to neoadjuvant chemotherapy (NAC) treatment that impair their functioning and quality of life (QoL). This study aimed to explore the effect of high-intensity aerobic interval training (HIIT) on quality of life and NAC side effects in women with BC.
METHODS
56 patients (48.56 (7.84) years, range 35-64 years) diagnosed locally advanced (stage II-III) ER + BC receiving doxorubicin/cyclophosphamide-based NAC were randomly assigned to the HIIT group and a control group (CG) for 6 months. The HIIT group performed 2 to 3 HIIT sessions per week according to the study protocol (4 × 4 minutes at 85%-95% peak heart rate (HR)). The CG followed the standard of care instructions by the oncologists. To assess the QoL participants completed the EORTC QLQ-C30 with the additional BC module of QLQ BR-23. Weekly self-reports on NAC side effects were collected through online survey.
RESULTS
Study data were analyzed for 37 participants (nHIIT = 17, nCON = 20) who reported at least 14 (60%) weeks. HIIT was effective to reduce BC symptom scale outcomes (ES = 0.113, = .048), and alleviate systemic therapy side effects (ES = 0.154, = .020) and cancer related symptoms (ES = 0.124, = .038). The most common side effect participants experienced at least 1 to 4 days/week was pain (average 50.9% and 56.8% for HIIT and CG, respectively), followed by sleep disturbances (average 50.9% and 49.9%, respectively). About 31% in both groups experienced sleep disturbances 5 to 7 days/week. The NAC induced physical, social and fatigue side effects had significantly lower incidence in HIIT group, while psychological side effects were significantly more common in training group.
CONCLUSIONS
HIIT is an effective physical exercise program to maintain higher quality of life and help to reduce some of NAC induced side effects for women with BC.
目的
本研究旨在探讨高强度间歇训练（HIIT）对接受多柔比星/环磷酰胺为基础的新辅助化疗（NAC）的局部晚期（Ⅱ-Ⅲ期）雌激素受体阳性（ER+）乳腺癌（BC）女性的生活质量（QoL）和 NAC 副作用的影响。
方法
56 例患者（48.56（7.84）岁，范围 35-64 岁）被诊断为局部晚期（Ⅱ-Ⅲ期）ER+BC，接受多柔比星/环磷酰胺为基础的 NAC，随机分为 HIIT 组和对照组（CG），进行 6 个月的治疗。HIIT 组根据研究方案每周进行 2-3 次 HIIT 训练（4×4 分钟，心率达到 85%-95%峰值）。CG 组遵循肿瘤医生的标准治疗建议。为评估 QoL，参与者完成 EORTC QLQ-C30 问卷和附加的 BC 模块 QLQ BR-23。通过在线调查每周收集 NAC 副作用的自我报告。
结果
对至少报告 14 周（60%）的 37 名参与者（nHIIT=17，nCON=20）进行了研究数据分析。HIIT 有效降低了 BC 症状量表的结果（ES=0.113，=0.048），减轻了系统治疗副作用（ES=0.154，=0.020）和癌症相关症状（ES=0.124，=0.038）。参与者至少每周经历 1-4 天的最常见副作用是疼痛（HIIT 和 CG 组的平均发生率分别为 50.9%和 56.8%），其次是睡眠障碍（平均发生率分别为 50.9%和 49.9%）。两组中约有 31%的人每周有 5-7 天出现睡眠障碍。HIIT 组 NAC 引起的身体、社会和疲劳副作用发生率明显较低，而训练组的心理副作用发生率明显较高。
结论
HIIT 是一种有效的体育锻炼方案，可以维持更高的生活质量，并有助于减轻接受 NAC 治疗的 BC 女性的一些副作用。
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