• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脓毒症患者体温与28天死亡率之间的关联：一项回顾性观察研究。

The association between body temperature and 28-day mortality in sepsis patients: A retrospective observational study.

作者信息

Yang Wei, Zhou Dan, Peng Hui, Jiang Huilin, Chen Weifeng

机构信息

Department of General Practice, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong Province, China.

Department of Emergency, The Second Affiliated Hospital, Guangzhou Medical University, No. 250 Changgang East Road, Guangzhou, 510260, Guangdong Province, China.

出版信息

Med Intensiva (Engl Ed). 2025 Apr;49(4):205-215. doi: 10.1016/j.medine.2024.08.004. Epub 2024 Nov 17.

DOI:10.1016/j.medine.2024.08.004
PMID:39551689
Abstract

OBJECTIVE

This study explored the association between body temperature and 28-day septic ICU hospital mortality.

DESIGN

Retrospective cohort analysis.

SETTING

208 ICUs in the United States.

PATIENTS OR PARTICIPANTS

Sepsis patients from 2014-2015 eICU Collaborative Research Database.

INTERVENTIONS

Binary logistic regression models, Generalized Additive Model (GAM), Two-Piece Binary Logistic Regression Model.

MAIN VARIABLES OF INTEREST

Body temperature, 28-day inpatient mortality.

RESULTS

Nonlinear relationship observed; hypothermia (≤36.67 ℃) associated with increased mortality (adjusted OR = 0.74, 95% CI: 0.70-0.80, p < 0.0001).

CONCLUSIONS

Hypothermia in sepsis correlates with higher mortality; rewarming's potential benefit warrants further exploration.

摘要

目的

本研究探讨体温与脓毒症患者入住重症监护病房28天死亡率之间的关联。

设计

回顾性队列分析。

地点

美国208个重症监护病房。

患者或参与者

来自2014 - 2015年电子重症监护病房协作研究数据库的脓毒症患者。

干预措施

二元逻辑回归模型、广义相加模型（GAM）、两段式二元逻辑回归模型。

主要研究变量

体温、28天住院死亡率。

结果

观察到非线性关系；体温过低（≤36.67℃）与死亡率增加相关（校正比值比=0.74，95%置信区间：0.70 - 0.80，p<0.0001）。

结论

脓毒症患者体温过低与较高死亡率相关；复温的潜在益处值得进一步探索。

相似文献

1
The association between body temperature and 28-day mortality in sepsis patients: A retrospective observational study.脓毒症患者体温与28天死亡率之间的关联：一项回顾性观察研究。
Med Intensiva (Engl Ed). 2025 Apr;49(4):205-215. doi: 10.1016/j.medine.2024.08.004. Epub 2024 Nov 17.
2
Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study.体温异常对严重脓毒症患者实施脓毒症集束化治疗方案及结局的影响：急性呼吸窘迫综合征、脓毒症和创伤急救聚焦治疗结局研究的回顾性亚分析。
Crit Care Med. 2019 May;47(5):691-699. doi: 10.1097/CCM.0000000000003688.
3
Association of Annual Intensive Care Unit Sepsis Caseload With Hospital Mortality From Sepsis in the United Kingdom, 2010-2016.2010-2016 年英国重症监护病房每年脓毒症发病例数与医院脓毒症死亡率的相关性。
JAMA Netw Open. 2021 Jun 1;4(6):e2115305. doi: 10.1001/jamanetworkopen.2021.15305.
4
Association between body temperature and all-cause mortality in patients with sepsis: analysis of the MIMIC-IV database.脓毒症患者体温与全因死亡率之间的关联：MIMIC-IV数据库分析
Eur J Med Res. 2024 Dec 26;29(1):630. doi: 10.1186/s40001-024-02219-2.
5
The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis.体温异常对严重脓毒症患者疾病严重程度及预后的影响：一项来自严重脓毒症多中心前瞻性调查的分析
Crit Care. 2013 Nov 13;17(6):R271. doi: 10.1186/cc13106.
6
Hypothermia predicts mortality in critically ill elderly patients with sepsis.低温预测脓毒症危重症老年患者的死亡率。
BMC Geriatr. 2010 Sep 27;10:70. doi: 10.1186/1471-2318-10-70.
7
Cluster analysis integrating age and body temperature for mortality in patients with sepsis: a multicenter retrospective study.基于年龄和体温的聚类分析在脓毒症患者死亡率预测中的应用：一项多中心回顾性研究。
Sci Rep. 2022 Jan 20;12(1):1090. doi: 10.1038/s41598-022-05088-z.
8
Association between hemoglobin and in-hospital mortality in critically ill patients with sepsis: evidence from two large databases.脓毒症重症患者血红蛋白水平与院内死亡率之间的关联：来自两个大型数据库的证据
BMC Infect Dis. 2024 Dec 19;24(1):1450. doi: 10.1186/s12879-024-10335-x.
9
Complementary Role of Hypothermia Identification to the Quick Sequential Organ Failure Assessment Score in Predicting Patients With Sepsis at High Risk of Mortality: A Retrospective Analysis From a Multicenter, Observational Study.低温识别对快速序贯器官衰竭评估评分在预测高死亡率脓毒症患者中的互补作用：一项来自多中心观察性研究的回顾性分析。
J Intensive Care Med. 2020 May;35(5):502-510. doi: 10.1177/0885066618761637. Epub 2018 Mar 15.
10
Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database.单次剂量依托咪酯与 ICU 脓毒症患者死亡率的增加无关：大型电子 ICU 数据库分析。
Crit Care Med. 2013 Mar;41(3):774-83. doi: 10.1097/CCM.0b013e318274190d.

引用本文的文献

1
Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.脓毒症相关性急性肾损伤的早期体温轨迹与短期预后
Sci Rep. 2025 Aug 29;15(1):31820. doi: 10.1038/s41598-025-17170-3.