Department of Medical Oncology, Ohio State University, James Cancer Center, Columbus, Ohio, USA.
Department of Pathology, Ohio State University, James Cancer Center, Columbus, Ohio, USA.
J Med Virol. 2024 Nov;96(11):e70086. doi: 10.1002/jmv.70086.
HPV viral E6 and E7 onco-proteins play a well-known role in carcinogenesis. Host genomic alterations also play a key role in the development of HPV-related oropharyngeal cancer and have been under-recognized. We describe a case series of 6 metastatic/locoregionally recurrent HPVOPSCC patients with FGFR alterations. HPVOPSCC presents with distinct pattern of spread both temporally and sites of recurrence compared to non-HPV-related oropharyngeal cancer. Identification and reporting of genomic alterations in HPV are crucial to the understanding of disease biology and could aid in development of novel therapeutics for these patients. In addition, use of circulating tumor DNA may lead to early detection and supplement imaging in the follow up of these patients. Loco-regional treatments may also play a key role in the management of metastatic HPV OPSCC depending on the pattern of presentation. Our case series highlights all these novelties that could lead to better treatment outcomes.
HPV 病毒 E6 和 E7 致癌蛋白在致癌作用中起着众所周知的作用。宿主基因组改变在 HPV 相关口咽癌的发展中也起着关键作用，但尚未得到充分认识。我们描述了 6 例转移性/局部复发性 HPV 口咽癌患者伴 FGFR 改变的病例系列。与非 HPV 相关的口咽癌相比，HPV 口咽癌在时间和复发部位上具有不同的扩散模式。HPV 中基因组改变的识别和报告对于了解疾病生物学至关重要，并可能有助于为这些患者开发新的治疗方法。此外，循环肿瘤 DNA 的使用可能会导致这些患者的早期检测，并在随访中补充影像学检查。局部区域治疗也可能根据表现模式在转移性 HPV 口咽癌的治疗中发挥关键作用。我们的病例系列强调了所有这些新的发现，这些发现可能会带来更好的治疗效果。
