肌肉减少症与衰老的生物学决定因素：老年科学视角的叙述性综述

Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.

作者信息

Nunes-Pinto Mariá, Bandeira de Mello Renato Gorga, Pinto Milena Nunes, Moro Cédric, Vellas Bruno, Martinez Laurent O, Rolland Yves, de Souto Barreto Philipe

机构信息

Gerontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France; Postgraduate Program in Medical Sciences (Endocrinology), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Postgraduate Program in Medical Sciences (Endocrinology), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; School of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Master of Public Health Program, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.

出版信息

Ageing Res Rev. 2025 Jan;103:102587. doi: 10.1016/j.arr.2024.102587. Epub 2024 Nov 19.

DOI:10.1016/j.arr.2024.102587

PMID:39571617

Abstract

BACKGROUND

The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.

METHODS

This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.

RESULTS

Among the twelve hallmarks of aging studied, there appears to be a substantial association between sarcopenia and mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, and altered intercellular communication. Although limited, preliminary evidence suggests a promising association between sarcopenia and genomic instability or stem cell exhaustion.

DISCUSSION

Overall, an imbalance in energy regulation, characterized by impaired mitochondrial energy production and alterations in circulatory markers, is commonly associated with sarcopenia and may reflect the interplay between aging physiology and sarcopenia biology.

摘要