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确诊为变应性支气管肺曲霉病患者的长期抗真菌治疗

Long-Term Antifungal Treatment in a Patient With Confirmed Allergic Bronchopulmonary Aspergillosis.

作者信息

Imran Aziz Hassan, Aziz Imran

机构信息

Internal Medicine, Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, GBR.

Respiratory Medicine, Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, GBR.

出版信息

Cureus. 2024 Oct 22;16(10):e72142. doi: 10.7759/cureus.72142. eCollection 2024 Oct.

Abstract

An allergic reaction to infections with Aspergillus fumigatus causes allergic bronchopulmonary aspergillosis (ABPA). This response often can worsen underlying symptoms of previously well-controlled diseases, such as asthma or cystic fibrosis. Due to the nature of the symptoms, patients with ABPA are often regarded as just having worsening asthma control or are treated for a different disease entirely. Even when diagnosed, the treatment is often formulaic and not tailored to the patient directly. This report will discuss the case of a 63-year-old man with a background of asthma who presented with recurrent chest infections, in which treatment with antibiotics and steroids did not resolve his symptoms. A diagnosis of ABPA was made following investigations, which has led to better control of his symptoms on long-term antifungal treatment.

摘要

对烟曲霉感染的过敏反应会引发变应性支气管肺曲霉病(ABPA)。这种反应常常会使先前病情得到良好控制的疾病(如哮喘或囊性纤维化)的潜在症状恶化。由于症状的性质,ABPA患者常常被认为只是哮喘控制情况恶化,或者被当作完全患有另一种疾病来治疗。即便确诊了,治疗往往也是千篇一律,没有直接针对患者进行量身定制。本报告将讨论一名63岁男性的病例,该患者有哮喘病史,出现反复的胸部感染,使用抗生素和类固醇治疗未能缓解其症状。经过检查后确诊为ABPA,长期抗真菌治疗使他的症状得到了更好的控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c3/11581136/b843a2555dcc/cureus-0016-00000072142-i01.jpg

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