McComish Department of Electrical Engineering and Computer Science, Jerome J. Lohr College of Engineering, South Dakota State University, Brookings, SD 57007, USA.
College of Ecological Environment and Urban Construction, Fujian University of Technology, Fuzhou 350118, China.
Biosensors (Basel). 2024 Oct 22;14(11):516. doi: 10.3390/bios14110516.
Transcutaneous carbon dioxide (TcPCO2) monitoring provides a non-invasive alternative to measuring arterial carbon dioxide (PaCO2), making it valuable for various applications, such as sleep diagnostics and neonatal care. However, traditional transcutaneous monitors are bulky, expensive, and pose risks such as skin burns. To address these limitations, we have introduced a compact, cost-effective CMOS imager-based sensor for TcPCO2 detection by utilizing colorimetric reactions with metal-organic framework (MOF)-based nano-hybrid materials. The sensor, with a colorimetric sensing array fabricated on an ultrathin PDMS membrane and then adhered to the CMOS imager surface, can record real-time sensing data through image processing without the need for additional optical components, which significantly reduces the sensor's size. Our system shows impressive sensitivity and selectivity, with a low detection limit of 26 ppm, a broad detection range of 0-2% CO, and strong resistance to interference from common skin gases. Feasibility tests on human subjects demonstrate the potential of this MOF-CMOS imager-based colorimetric sensor for clinical applications. Additionally, its compact design and responsiveness make it suitable for sports and exercise settings, offering valuable insights into respiratory function and performance. The sensing system's compact size, low cost, and reversible and highly sensitive TcPCO2 monitoring capability make it ideal for integration into wearable devices for remote health tracking.
经皮二氧化碳（TcPCO2）监测提供了一种替代测量动脉二氧化碳（PaCO2）的非侵入性方法，使其在各种应用中具有价值，如睡眠诊断和新生儿护理。然而，传统的经皮监测仪体积大、成本高，并且存在皮肤烧伤等风险。为了解决这些限制，我们引入了一种基于 CMOS 成像器的紧凑、经济高效的传感器，用于通过利用基于金属有机骨架（MOF）的纳米混合材料的比色反应来检测 TcPCO2。该传感器具有在超薄 PDMS 膜上制造的比色传感阵列，然后粘附在 CMOS 成像器表面上，可以通过图像处理记录实时传感数据，而无需额外的光学元件，这大大减小了传感器的尺寸。我们的系统显示出令人印象深刻的灵敏度和选择性，检测限低至 26ppm，检测范围宽达 0-2%CO，并且对常见皮肤气体的干扰具有很强的抵抗力。对人体的可行性测试表明，这种基于 MOF-CMOS 成像器的比色传感器在临床应用中具有潜力。此外，其紧凑的设计和响应能力使其适合运动和锻炼环境，为呼吸功能和性能提供有价值的见解。该传感系统的紧凑尺寸、低成本以及可重复使用和高度敏感的 TcPCO2 监测能力使其成为集成到可穿戴设备中进行远程健康跟踪的理想选择。
