The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China.
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Biomolecules. 2024 Oct 25;14(11):1361. doi: 10.3390/biom14111361.
Cellular senescence is a state of permanent cell cycle arrest and plays an important role in many vascular lesions. This study found that the cells of diabetic patients have more characteristics of senescence, which may cause microvascular complications. Cell senescence, as one of the common fates of cells, links microangiopathy and diabetes. Cell senescence in a high-glucose environment can partially elucidate the mechanism of diabetic microangiopathy, and various types of cellular senescence induced by it can promote the progression of diabetic microangiopathy. Still, the molecular mechanism of microangiopathy-related cellular senescence has not yet been clearly studied. Building on recent research evidence, we herein summarize the fundamental mechanisms underlying the development of cellular senescence in various microangiopathies associated with diabetes. We gradually explain how cellular senescence serves as a key driver of diabetic microangiopathy. At the same time, the treatment of basic senescence mechanisms such as cellular senescence may have a great impact on the pathogenesis of the disease, may be more effective in preventing the development of diabetic microangiopathy, and may provide new ideas for the clinical treatment and prognosis of diabetic microangiopathy.
细胞衰老（Cellular senescence）是一种细胞周期永久停滞的状态，在许多血管病变中发挥着重要作用。本研究发现，糖尿病患者的细胞具有更多衰老特征，这可能导致微血管并发症。细胞衰老作为细胞的常见命运之一，将微血管病变与糖尿病联系起来。高糖环境中的细胞衰老部分阐明了糖尿病性微血管病变的机制，而其诱导的各种类型的细胞衰老则促进了糖尿病性微血管病变的进展。然而，与糖尿病相关的微血管病变相关细胞衰老的分子机制尚未得到明确研究。基于最近的研究证据，我们在此总结了与糖尿病相关的各种微血管病变中细胞衰老发展的基本机制。我们逐渐解释了细胞衰老如何作为糖尿病性微血管病变的关键驱动因素。同时，对细胞衰老等基本衰老机制的治疗可能对疾病的发病机制有重大影响，可能更有效地预防糖尿病性微血管病变的发展，并为糖尿病性微血管病变的临床治疗和预后提供新的思路。
