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成人及老年人社区获得性呼吸道病毒感染临床实际情况的观察性研究

Observational Study on the Clinical Reality of Community-Acquired Respiratory Virus Infections in Adults and Older Individuals.

作者信息

Nagasawa Masayuki, Udagawa Tomohiro, Kato Tomoyuki, Tanaka Ippei, Yamamoto Ren, Sakaguchi Hayato, Sekikawa Yoshiyuki

机构信息

Department of Infection Control, Musashino Red Cross Hospital, 1-26-1, Kyonan-cho, Musashino, Tokyo 180-8610, Japan.

Department of Pediatrics, Musashino Red Cross Hospital, 1-26-1, Kyonan-cho, Musashino, Tokyo 180-8610, Japan.

出版信息

Pathogens. 2024 Nov 9;13(11):983. doi: 10.3390/pathogens13110983.

DOI:10.3390/pathogens13110983
PMID:39599536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11597395/
Abstract

The impact of common respiratory virus infections on adults and older individuals in the community is unclear, excluding seasonal influenza viruses. We examined FilmArray® tests performed on 1828 children aged <10 years and 10,803 adults, including cases with few respiratory symptoms, between January 2021 and June 2024. Approximately 80% of the children tested positive for ≥1 viruses, while 9.5% of the adults tested positive mostly for severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). Besides SARS-CoV-2 infection, 66 out of 97 patients (68.0%) aged >60 years with rhinovirus/enterovirus (RV/EV), respiratory syncytial virus (RSV), parainfluenza virus-3 (PIV-3), or human metapneumovirus (hMPV) infection required hospitalization, of whom seven died; 26 out of 160 patients (16.3%) aged <60 years required hospitalization mostly because of deterioration of bronchial asthma, with no reported deaths. In older patients with RV/EV infection, three with few respiratory symptoms died due to worsened heart failure. Although the frequency of common respiratory virus infections in older adults is low, it may be overlooked because of subclinical respiratory symptoms, and its clinical significance in worsening comorbidities in older adults should not be underestimated.

摘要

除季节性流感病毒外，常见呼吸道病毒感染对社区中的成年人和老年人的影响尚不清楚。我们检查了2021年1月至2024年6月期间对1828名10岁以下儿童和10803名成年人进行的FilmArray®检测，其中包括呼吸道症状轻微的病例。大约80%的儿童检测出≥1种病毒呈阳性，而9.5%的成年人检测呈阳性，主要是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。除SARS-CoV-2感染外，97例年龄>60岁的鼻病毒/肠道病毒（RV/EV）、呼吸道合胞病毒（RSV）、副流感病毒3型（PIV-3）或人偏肺病毒（hMPV）感染患者中有66例（68.0%）需要住院治疗，其中7例死亡；160例年龄<60岁的患者中有26例（16.3%）需要住院治疗，主要是因为支气管哮喘恶化，无死亡报告。在老年RV/EV感染患者中，3例呼吸道症状轻微的患者因心力衰竭加重死亡。尽管老年人中常见呼吸道病毒感染的频率较低，但由于亚临床呼吸道症状可能会被忽视，其在加重老年人合并症方面的临床意义不应被低估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/bc36e5aa83d8/pathogens-13-00983-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/a0cfedf36580/pathogens-13-00983-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/9679bae8bbbf/pathogens-13-00983-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/c72ee224d78b/pathogens-13-00983-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/7843f2f29795/pathogens-13-00983-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/bc36e5aa83d8/pathogens-13-00983-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/a0cfedf36580/pathogens-13-00983-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/9679bae8bbbf/pathogens-13-00983-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/c72ee224d78b/pathogens-13-00983-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/7843f2f29795/pathogens-13-00983-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e51/11597395/bc36e5aa83d8/pathogens-13-00983-g005.jpg

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