JNJ-A07 这种抗病毒药物通过经血液传播的方式，能显著降低蚊子传播登革热病毒的能力。

The antiviral JNJ-A07 significantly reduces dengue virus transmission by mosquitoes when delivered via blood-feeding.

机构信息

KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.

KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug & Vaccine Research Group, 3000 Leuven, Belgium.

出版信息

Sci Adv. 2024 Nov 29;10(48):eadr8338. doi: 10.1126/sciadv.adr8338. Epub 2024 Nov 27.

DOI:10.1126/sciadv.adr8338

PMID:39602538

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11601208/

Abstract

Dengue virus (DENV) is the most widespread mosquito-borne virus worldwide, but no antiviral therapies are available yet. The pan-serotype DENV inhibitor JNJ-A07 has shown potent activity in a mouse model. It remains unknown whether an antiviral drug ingested by mosquitoes could inhibit virus replication and thus reduce transmission to other hosts. Here, we investigated the antiviral activity of JNJ-A07 when administered in the blood meal to mosquitoes. JNJ-A07 blocked DENV-2 transmission by the mosquitoes in both pre-exposure and post-exposure settings. In addition, JNJ-A07 remained in the mosquito bodies for 7 days after blood meal. Reductions of DENV systemic infection in the mosquitoes suggested a potential for decreased proportions of DENV outbreaks in a simulated environment when the mosquitoes ingested JNJ-A07 via the blood meal.

摘要

登革热病毒（DENV）是全球分布最广泛的蚊媒病毒，但目前尚无抗病毒疗法。泛血清型 DENV 抑制剂 JNJ-A07 在小鼠模型中表现出很强的活性。目前尚不清楚蚊子摄入的抗病毒药物是否能抑制病毒复制，从而减少向其他宿主的传播。在这里，我们研究了 JNJ-A07 在蚊子的血餐中给药时的抗病毒活性。JNJ-A07 阻断了蚊子在预先暴露和暴露后环境中传播 DENV-2。此外，JNJ-A07 在血餐摄入后 7 天仍存在于蚊子体内。在模拟环境中，当蚊子通过血餐摄入 JNJ-A07 时，蚊子体内 DENV 的系统感染减少，这表明 DENV 爆发的比例可能降低。