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2015 - 2018年赞比亚一个技术援助项目期间结核病的流行病学趋势

Epidemiological trends in TB during a technical assistance project, Zambia, 2015-2018.

作者信息

Ota M, Mfungwe V, Masitano C, Matsuoka Y, Hirao S, Amano S, Tanaka Y, Daka S, Oniki-Goto M, Phiri M, Mtonga Z, Changala M, Samungole G K V, Msiska C Y

机构信息

Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan.

JATA Zambia, Lusaka, Zambia.

出版信息

Public Health Action. 2024 Dec 1;14(4):175-180. doi: 10.5588/pha.24.0028. eCollection 2024 Dec.

Abstract

SETTING

Three health facilities: Chongwe Health Centre (CHC), Chongwe District Hospital (CDH), and Ngwerere Health Centre (NHC) in Chongwe District, Lusaka Province, Zambia.

OBJECTIVE

To describe the epidemiological trend of TB in 2015-2018, with the 2014 data as baseline.

DESIGN

This was an observational study.

RESULTS

At CHC, CDH, and NHC, 457, 851 and 85 cases, respectively, of all types of TB were registered in 2014-2018. The numbers of patients with presumptive TB at CHC and CDH increased from 606 and 406, respectively, in 2014 to 1068 and 1848, respectively, in 2018. The proportion of patients with bacteriologically positive TB among patients with presumptive TB decreased at CHC and CDH from over 10% in 2014 to less than 5% in late 2018. The treatment success rates decreased at CHC and CDH in 2017 from respectively 93.7% and 93.0% in 2014 to 69.1% and 73.0% in 2017. GeneXpert equipment was installed at CHC in 2016 and CDH in 2017.

CONCLUSION

After introducing GeneXpert equipment at CHC and CDH, the proportion of bacteriologically-positive TB among presumptive TB significantly decreased because of the high number of patients with presumptive TB screened; however, it may have also caused treatment success rates to have stumbled.

摘要

研究背景

赞比亚卢萨卡省琼圭区的三个卫生机构,即琼圭健康中心(CHC)、琼圭区医院(CDH)和恩韦雷雷健康中心(NHC)。

研究目的

以2014年数据为基线,描述2015 - 2018年结核病的流行病学趋势。

研究设计

这是一项观察性研究。

研究结果

2014 - 2018年期间,CHC、CDH和NHC分别登记了457例、851例和85例各类结核病病例。CHC和CDH疑似结核病患者数量分别从2014年的606例和406例增加到2018年的1068例和1848例。CHC和CDH疑似结核病患者中细菌学阳性结核病患者的比例从2014年的超过10%下降到2018年末的不到5%。2017年CHC和CDH的治疗成功率分别从2014年的93.7%和93.0%下降到69.1%和73.0%。CHC于2016年安装了GeneXpert设备,CDH于2017年安装。

研究结论

在CHC和CDH引入GeneXpert设备后,由于筛查的疑似结核病患者数量众多,疑似结核病中细菌学阳性结核病患者比例显著下降;然而,这也可能导致治疗成功率下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7194/11604154/87c783a50b96/pha24-0028f1.jpg

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