缺铁性贫血儿童每日补铁与间歇补铁的荟萃分析。
Daily versus intermittent iron supplementation among children with iron deficiency anemia: A meta-analysis.
作者信息
Alblewi Sawsan Mohammed
机构信息
Sawsan Mohammed Alblewi Pediatrics Department, Faculty of Medicine, University of Tabuk, Saudi Arabia, PO Box 3378 Tabuk 51941, Saudi Arabia.
出版信息
Pak J Med Sci. 2024 Dec;40(11):2732-2738. doi: 10.12669/pjms.40.11.10344.
OBJECTIVE
This meta-analysis aimed to investigate daily versus intermittent iron supplementation among children.
METHODS
The author searched the Cochrane Library, PubMed, Medline, and Google Scholar for randomized controlled trials and compared daily versus intermittent iron supplementation. The keywords iron deficiency anemia, iron therapy, daily, twice per week, and once weekly were used. The search was limited to the period January 2012 up to November 2023. The age of participant range from two months to 18 years.
RESULT
Out of the 735 studies, 540 were eligible after removal of duplication, of them, 28 full texts were screened and only 10 studies were included. Daily iron supplementation was better in improving hemoglobin odd ratio, 0.41, 95 CI, 0.38-0.44, Z=26.53, and p-Value <0.001 than intermittent prescription odd ratio, 0.69, 95 CI, 0.67-0.72, Z=49.98, and P-value < 0.001.
CONCLUSION
Daily supplementation increased hemoglobin more compared to weekly or twice/week among children with iron deficiency anemia. Further larger studies assessing tolerance and compliance are needed.
目的
本荟萃分析旨在研究儿童每日补铁与间歇性补铁的情况。
方法
作者检索了考克兰图书馆、PubMed、Medline和谷歌学术搜索中的随机对照试验，比较每日补铁与间歇性补铁的效果。使用了关键词缺铁性贫血、铁疗法、每日、每周两次和每周一次。检索范围限于2012年1月至2023年11月期间。参与者年龄范围为两个月至18岁。
结果
在735项研究中，去除重复项后有540项符合条件，其中筛选了28篇全文，仅纳入10项研究。每日补铁在改善血红蛋白方面效果更好，优势比为0.41，95%置信区间为0.38 - 0.44，Z = 26.53，P值<0.001；而间歇性补铁的优势比为0.69，95%置信区间为0.67 - 0.72，Z = 49.98，P值<0.001。
结论
与每周或每周两次补铁相比，每日补铁能使缺铁性贫血儿童的血红蛋白增加更多。需要进一步开展更大规模的研究来评估耐受性和依从性。
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