[树突状细胞在类风湿关节炎免疫代谢中的作用研究进展]
[Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis].
作者信息
Han Guangtao, Sun Shuo, Wang Qin, Kang Pengde
机构信息
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024 Dec 15;38(12):1537-1541. doi: 10.7507/1002-1892.202408002.
OBJECTIVE
To review the role of dendritic cells (DC) in immune metabolism of rheumatoid arthritis (RA).
METHODS
Literature on the role of DC in the immune metabolism of RA was extensively reviewed in recent years, and the metabolic characteristics of RA, the role of DC in RA, the correlation between the immune metabolism of DC and pathogenesis of RA, and the treatment were summarized and analyzed.
RESULTS
DC promotes the progression of RA under hypoxia, increased glycolysis, inhibition of oxidative phosphorylation, and decreased lipid metabolism. Moreover, many DCs (especially conventional DC and monocyte-derived DC) have different functions and phenotypic characteristics in RA, which are closely related to the occurrence and development of RA.
CONCLUSION
DC plays an important role in the immune metabolism of RA, and immunometabolism therapy based on DC can provide targeted therapy for the treatment of RA.
目的
综述树突状细胞（DC）在类风湿关节炎（RA）免疫代谢中的作用。
方法
广泛回顾近年来关于DC在RA免疫代谢中作用的文献，并总结分析RA的代谢特征、DC在RA中的作用、DC免疫代谢与RA发病机制的相关性以及治疗情况。
结果
在缺氧、糖酵解增加、氧化磷酸化受抑制和脂质代谢降低的情况下，DC促进RA的进展。此外，许多DC（尤其是传统DC和单核细胞衍生DC）在RA中具有不同的功能和表型特征，这与RA的发生发展密切相关。
结论
DC在RA免疫代谢中起重要作用，基于DC的免疫代谢治疗可为RA的治疗提供靶向治疗。
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