动脉瘤性蛛网膜下腔出血后振荡活动和认知功能的改变。
Alterations of oscillatory activity and cognitive function after aneurysmal subarachnoid hemorrhage.
作者信息
Liu Peng, Han Chuanliang, Zhang Tongyu, Xu Yueqiao, Yang Kun, Li Yuxia, Ye Zhennan, Wang Changming, Zhang Hongqi
机构信息
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China.
出版信息
Int J Surg. 2025 Feb 1;111(2):1919-1928. doi: 10.1097/JS9.0000000000002190.
BACKGROUND
Aneurysmal subarachnoid hemorrhage (aSAH) can lead to cognitive impairment (CI), but underlying neural mechanisms remain to be elucidated.
MATERIALS AND METHODS
To predict long-term CI after aSAH, resting electroencephalography (EEG) was measured in 112 patients hospitalized with a diagnosis of aSAH ( n = 66) or unruptured intracranial aneurysms (controls) ( n = 46). A neuropsychological battery was administered 8-24 months after discharge.
RESULTS
Power spectrum analysis in the parietal-occipital lobe showed significantly higher power theta vs. alpha oscillations in patients with CI after aSAH. The power of theta and alpha oscillations were significantly correlated with multiple cognitive scale scores on the neuropsychological battery. A neural model was established, which showed that connectivity between inhibitory and excitatory neurons in neural circuits contributed to changes in theta and alpha oscillations and CI in aSAH.
CONCLUSION
The data collection, analysis, and computational model established in this study can serve as a new paradigm for other clinical studies investigating CI.
背景
动脉瘤性蛛网膜下腔出血（aSAH）可导致认知障碍（CI），但其潜在的神经机制仍有待阐明。
材料与方法
为预测aSAH后的长期CI，对112例住院患者进行了静息脑电图（EEG）测量，其中诊断为aSAH的患者66例，未破裂颅内动脉瘤患者（对照组）46例。出院后8 - 24个月进行神经心理测试。
结果
顶枕叶的功率谱分析显示，aSAH后发生CI的患者中，θ波与α波振荡的功率显著更高。θ波和α波振荡的功率与神经心理测试中的多个认知量表评分显著相关。建立了一个神经模型，该模型显示神经回路中抑制性和兴奋性神经元之间的连接有助于aSAH中θ波和α波振荡的变化以及CI的发生。
结论
本研究中建立的数据收集、分析和计算模型可作为其他研究CI的临床研究的新范例。
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