Han Eui-Jeong, Ahn Ji-Seon, Choi Yu-Jin, Kim Da-Hye, Choi Jong-Soon, Chung Hea-Jong
Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.
Research Center for Materials Analysis, Korea Basic Science Institute, Daejeon 34133, Republic of Korea; College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189251. doi: 10.1016/j.bbcan.2024.189251. Epub 2024 Dec 22.
The gut microbiome, a complex community of trillions of microorganisms in the intestines, is crucial in maintaining human health. Recent advancements in microbiome research have unveiled a compelling link between the gut microbiome and cancer development and progression. Alterations in the composition and function of the gut microbiome, known as dysbiosis, have been implicated in various types of cancer, including, esophageal, liver, colon, pancreatic, and gastrointestinal. However, the specific gut microbial strains associated with the development or progression of cancers in various tissues remain largely unclear. Here, we summarize current research findings on the gut microbiome of multiple cancers. This review aims to identify key gut microbial targets that closely influence cancer development based on current research findings. To accurately evaluate the effectiveness of the gut microbiome as a clinical tool for cancer, further research is needed to explore its potential as a biomarker and therapeutic strategy.
肠道微生物群是肠道中数万亿微生物组成的复杂群落,对维持人类健康至关重要。微生物群研究的最新进展揭示了肠道微生物群与癌症发生和发展之间存在令人信服的联系。肠道微生物群的组成和功能改变,即生态失调,与包括食管癌、肝癌、结肠癌、胰腺癌和胃肠道癌在内的各种癌症有关。然而,与各种组织中癌症发生或发展相关的特定肠道微生物菌株在很大程度上仍不清楚。在这里,我们总结了目前关于多种癌症肠道微生物群的研究结果。本综述旨在根据当前研究结果确定密切影响癌症发展的关键肠道微生物靶点。为了准确评估肠道微生物群作为癌症临床工具的有效性,需要进一步研究以探索其作为生物标志物和治疗策略的潜力。