含席夫碱的新型丹皮酚酯衍生物的合成、抗卵菌和抗真菌活性
Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base.
作者信息
Zhang Xiaofang, Guo Xiaolong, Yin Wanying, Wang Ruiguang, Tian Yuee, Sun Huilu, Xu Shaobin, Shuang Shaoyan, Huang Xiaobo, Chen Genqiang, Che Zhiping
机构信息
Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticultrue and Plant Protection, Henan University of Science and Technology, Luoyang, China.
出版信息
Nat Prod Res. 2024 Dec 27:1-10. doi: 10.1080/14786419.2024.2426205.
To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (, , , and ) were prepared, and their structures were well characterised by H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, and we assessed. Amongst evaluated compounds, 1) Compounds and displayed good anti-oomycete against , with EC values of 116.50 and 88.86 mg/L, respectively. 2) Compounds and exhibited prominent anti-fungal against , with EC values of 66.73 and 29.33 mg/L, respectively. 3) This study suggested that the introduction of nitro at the C5 position of paeonol could improve its bioactivity against and . The results of this study pave the way for further design and development of paeonol derivatives as plant anti-oomycetes and anti-fungal agents in crop protection.
为了发现基于生物合理天然产物的农药，制备了一系列含有席夫碱的丹皮酚酯衍生物（、、和），并通过核磁共振氢谱（H NMR）和高分辨质谱（HRMS）对其结构进行了充分表征。此外，我们评估了这些化合物作为抗卵菌和抗真菌剂对两种严重农业病害和的生物活性。在所评估的化合物中，1）化合物和对表现出良好的抗卵菌活性，其半数有效浓度（EC）值分别为116.50和88.86mg/L。2）化合物和对表现出显著的抗真菌活性，其EC值分别为66.73和29.33mg/L。3）本研究表明，在丹皮酚的C5位引入硝基可提高其对和的生物活性。本研究结果为进一步设计和开发丹皮酚衍生物作为作物保护中的植物抗卵菌和抗真菌剂铺平了道路。
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