Cross Kaylen, Vetter Stefan W, Alam Yousuf, Hasan Md Zahidul, Nath Anupom Deb, Leclerc Estelle
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA.
Biomolecules. 2024 Dec 4;14(12):1550. doi: 10.3390/biom14121550.
Since its discovery in 1992, the receptor for advanced glycation end products (RAGE) has emerged as a key receptor in many pathological conditions, especially in inflammatory conditions. RAGE is expressed by most, if not all, immune cells and can be activated by many ligands. One characteristic of RAGE is that its ligands are structurally very diverse and belong to different classes of molecules, making RAGE a promiscuous receptor. Many of RAGE ligands are damaged associated molecular patterns (DAMPs) that are released by cells under inflammatory conditions. Although RAGE has been at the center of a lot of research in the past three decades, a clear understanding of the mechanisms of RAGE activation by its ligands is still missing. In this review, we summarize the current knowledge of the role of RAGE and its ligands in inflammation.
自1992年被发现以来，晚期糖基化终末产物受体（RAGE）已成为许多病理状况尤其是炎症状态下的关键受体。RAGE在大多数（即便不是全部）免疫细胞中表达，并且可被多种配体激活。RAGE的一个特点是其配体在结构上非常多样，属于不同类别的分子，这使得RAGE成为一种多配体受体。RAGE的许多配体是炎症条件下细胞释放的损伤相关分子模式（DAMPs）。尽管在过去三十年里RAGE一直是大量研究的核心，但对其配体激活RAGE的机制仍缺乏清晰的认识。在这篇综述中，我们总结了目前关于RAGE及其配体在炎症中作用的知识。
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