Harutyunyan Vachagan, Ottosen Ann, Burke Rachel M, Ehrhardt Derek, Shirey Meredith, Durham Rissa, Woods David
World Health Organization, 1211 Geneva, Switzerland.
UNICEF, 2150 Copenhagen, Denmark.
Vaccines (Basel). 2024 Dec 4;12(12):1369. doi: 10.3390/vaccines12121369.
As we commemorate 50 years of the Expanded Programme on Immunization (EPI), the global mission to eradicate polio stands at a critical juncture. While remarkable progress has been made over the past decades, ensuring a steady supply of polio vaccines remains a significant challenge that could undermine these achievements. This manuscript aims to address the complexities of polio vaccine security within the context of the Immunization Agenda 2030 (IA2030) and the Global Polio Eradication Strategy 2022-2029, proposing actionable strategies to strengthen the vaccine supply. This manuscript analyzes obstacles to vaccine security, including supply disruptions and market uncertainties. It presents the Polio Vaccine Security Framework as a key strategy for addressing these challenges. Data were gathered from Global Polio Eradication Initiative (GPEI) reports, consultations with key stakeholders, and analyses of past vaccine shortages. The findings indicate that the primary risks to vaccine security include the lack of a coherent long-term policy framework on polio vaccination, the absence of a clear polio vaccine development roadmap, and insufficient long-term, predictable forecasting. Additionally, stronger coordination is needed between stakeholders involved in vaccine supply, polio containment, and research, as well as addressing challenges related to financing and access to resources. A robust, adaptable, and sustainable approach to vaccine security, proposed in the Polio Vaccine Security Framework, is critical to achieving and sustaining polio eradication. Collaboration among policymakers, manufacturers, and stakeholders to implement it is essential to ensure the uninterrupted supply of polio vaccines, protecting the progress made over the past half century, and preventing a resurgence of poliovirus in the future.
在我们纪念扩大免疫规划（EPI）实施50周年之际，全球根除脊髓灰质炎的使命正处于关键时刻。尽管在过去几十年里取得了显著进展，但确保脊髓灰质炎疫苗的稳定供应仍然是一项重大挑战，可能会破坏这些成就。本手稿旨在探讨《2030年免疫议程》（IA2030）和《2022 - 2029年全球根除脊髓灰质炎战略》背景下脊髓灰质炎疫苗安全的复杂性，提出加强疫苗供应的可行策略。本手稿分析了疫苗安全的障碍，包括供应中断和市场不确定性。它提出了脊髓灰质炎疫苗安全框架作为应对这些挑战的关键策略。数据收集自全球根除脊髓灰质炎行动（GPEI）报告、与关键利益相关者的磋商以及对过去疫苗短缺情况的分析。研究结果表明，疫苗安全的主要风险包括缺乏关于脊髓灰质炎疫苗接种的连贯长期政策框架、没有明确的脊髓灰质炎疫苗研发路线图以及长期可预测性预测不足。此外，参与疫苗供应、脊髓灰质炎防控和研究的利益相关者之间需要更强有力的协调，同时要应对与融资和资源获取相关的挑战。脊髓灰质炎疫苗安全框架中提出的一种强大、适应性强且可持续的疫苗安全方法对于实现和维持根除脊髓灰质炎至关重要。政策制定者、制造商和利益相关者之间的合作以实施该方法对于确保脊髓灰质炎疫苗的不间断供应、保护过去半个世纪取得的进展以及防止未来脊髓灰质炎病毒卷土重来至关重要。
