确定[F]氟代甲磺酸去甲肾上腺素正电子发射断层扫描（PET）中视觉淀粉样蛋白阳性的临界值。
Establishing cutoff values for visual amyloid positivity in [F]flutemetamol PET.
作者信息
Park Yong-Jin, Moon So Young, Yoon Joon-Kee, Lee Su-Jin, An Young-Sil
机构信息
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, Korea.
Department of Neurology, Ajou University School of Medicine, Suwon, Korea.
出版信息
EJNMMI Res. 2025 Jan 8;15(1):1. doi: 10.1186/s13550-024-01193-4.
BACKGROUND
This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal was to determine cutoff values that enhance diagnostic accuracy and assist clinicians in reliably identifying amyloid positivity.
RESULTS
The identified cutoff values for visual amyloid positivity were > 1.6 for the cerebellar gray matter, > 1.38 for the whole cerebellum, and > 0.63 for the pons, yielding high sensitivity (95.5%, 94.5%, and 95.8%, respectively) and specificity (91.2%, 94.3%, and 95.2%, respectively).
CONCLUSIONS
The SUVR cutoff values demonstrated excellent diagnostic performance, supporting their clinical use in assessing visual amyloid positivity in [F]FMM PET imaging.
背景
本研究旨在确定在[F]氟替美莫（FMM）正电子发射断层扫描（PET）成像中使用标准化摄取值比率（SUVR）进行视觉淀粉样蛋白阳性判断的最佳临界值。鉴于淀粉样蛋白评估存在变异性，我们的目标是确定能够提高诊断准确性并帮助临床医生可靠识别淀粉样蛋白阳性的临界值。
结果
确定的视觉淀粉样蛋白阳性临界值为：小脑灰质>1.6，整个小脑>1.38，脑桥>0.63，敏感性分别为95.5%、94.5%和95.8%，特异性分别为91.2%、94.3%和95.2%。
结论
SUVR临界值显示出优异的诊断性能，支持其在[F]FMM PET成像中评估视觉淀粉样蛋白阳性的临床应用。
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