对2型糖尿病并发症分子基础的见解。

Insights into the molecular underpinning of type 2 diabetes complications.

作者信息

Singh Archit, Bocher Ozvan, Zeggini Eleftheria

机构信息

Technical University of Munich (TUM), TUM School of Medicine and Health, Graduate School of Experimental Medicine and Health Sciences, Ismaninger Straße 22, Munich 81675, Germany.

Institute of Translational Genomics, Helmholtz Zentrum München- German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg 85764, Germany.

出版信息

Hum Mol Genet. 2025 Mar 7;34(6):469-480. doi: 10.1093/hmg/ddae203.

DOI:10.1093/hmg/ddae203

PMID:39807636

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11891870/

Abstract

Type 2 diabetes (T2D) complications pose a significant global health challenge. Omics technologies have been employed to investigate these complications and identify the biological pathways involved. In this review, we focus on four major T2D complications: diabetic kidney disease, diabetic retinopathy, diabetic neuropathy, and cardiovascular complications. We discuss advancements in omics research, summarizing findings from genetic, epigenomic, transcriptomic, proteomic, and metabolomic studies across different ancestries and disease-relevant tissues. We stress the importance of integrating multi-omics techniques to elucidate the biological mechanisms underlying T2D complications and advocate for ancestrally diverse studies. Ultimately, these insights will improve risk prediction for T2D complications and inform translation strategies.

摘要

2型糖尿病（T2D）并发症对全球健康构成了重大挑战。组学技术已被用于研究这些并发症并确定其中涉及的生物学途径。在本综述中，我们重点关注四种主要的T2D并发症：糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变和心血管并发症。我们讨论了组学研究的进展，总结了来自不同种族和疾病相关组织的遗传、表观基因组、转录组、蛋白质组和代谢组学研究的结果。我们强调整合多组学技术以阐明T2D并发症潜在生物学机制的重要性，并提倡开展不同种族的研究。最终，这些见解将改善T2D并发症的风险预测并为转化策略提供依据。