用于延长血液循环时间的金纳米颗粒的最佳尺寸和聚乙二醇涂层：已发表数据的统计分析
Optimal size and PEG coating of gold nanoparticles for prolonged blood circulation: a statistical analysis of published data.
作者信息
Nevozhay Dmitry, Rauch Ronald, Wang Zhongya, Sokolov Konstantin V
机构信息
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center Houston TX 77030 USA
Department of Biostatistics, The University of Texas MD Anderson Cancer Center Houston TX 77030 USA.
出版信息
Nanoscale Adv. 2025 Jan 13;7(3):722-727. doi: 10.1039/d4na00782d. eCollection 2025 Jan 28.
This study presents a statistical analysis of how gold nanoparticle (GNP) size and polyethylene glycol (PEG) coating molecular weight (MW) affect the circulation of nanoparticles in blood. We showed a non-linear relationship with interaction between GNP size and PEG MW. The findings revealed a threshold effect, and recommendations for GNP coating are discussed.
本研究对金纳米颗粒（GNP）大小和聚乙二醇（PEG）涂层分子量（MW）如何影响纳米颗粒在血液中的循环进行了统计分析。我们展示了GNP大小与PEG MW之间相互作用的非线性关系。研究结果揭示了一种阈值效应，并讨论了关于GNP涂层的建议。
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