Wibawa Kevin, Wiyono Lidia Debby, Dewangga Raditya, Sumarna Arief, Syamsuri Wizhar, Ariffudin Yandi, Suhendiwijaya Suhendiwijaya, Syah Pangeran Akbar
Department of Cardiology and Vascular Medicine, Rumah Sakit Umum Daerah Gunung Jati, Kesambi Street No. 56, Cirebon, West Java, 45134, Indonesia.
Department of Cardiology and Vascular Medicine, Rumah Sakit Hasan Sadikin, Bandung, Indonesia.
Egypt Heart J. 2025 Jan 15;77(1):12. doi: 10.1186/s43044-025-00607-5.
Acute myocardial infarction during pregnancy is a rare condition with an incidence of 1 to 10 per 100,000 deliveries. ST-elevation myocardial infarction (STEMI) is dominating the clinical presentation. It is estimated that 29% of the patients had normal coronary arteries, and hyperthyroidism may be associated with coronary vasospasm.
A 30-year-old pregnant woman was referred with inferior STEMI post-failed fibrinolytic therapy. Her hospitalization course was complicated by non-sustained ventricular tachycardia and cardiogenic shock. Coronary angiography revealed normal coronary arteries without intracoronary thrombus, coronary dissection, or coronary atherosclerotic lesion. Laboratory test showed high Free T4 2.71 ng/dL and low TSH < 0.05 mlU/mL. Patient's condition and hospitalization course were significantly improved after the initiation of hyperthyroid therapy. We suspected a hyperthyroid-induced coronary vasospasm as a potential etiology of myocardial infarction with non-obstructive coronary artery (MINOCA) in this patient.
Although MINOCA due to hyperthyroidism is a rare finding among pregnant young woman, recognizing this etiology is a paramount of importance due to improved survival with appropriate and specific therapy.
妊娠期急性心肌梗死是一种罕见疾病,发病率为每10万次分娩中有1至10例。ST段抬高型心肌梗死(STEMI)是主要的临床表现形式。据估计,29%的患者冠状动脉正常,甲状腺功能亢进可能与冠状动脉痉挛有关。
一名30岁孕妇因纤维蛋白溶解疗法失败后出现下壁STEMI前来就诊。她的住院过程因非持续性室性心动过速和心源性休克而复杂化。冠状动脉造影显示冠状动脉正常,无冠状动脉内血栓、冠状动脉夹层或冠状动脉粥样硬化病变。实验室检查显示游离T4升高至2.71 ng/dL,促甲状腺激素降低至<0.05 mIU/mL。在开始进行甲状腺功能亢进治疗后,患者的病情和住院过程有了显著改善。我们怀疑甲状腺功能亢进引起的冠状动脉痉挛是该患者心肌梗死合并非阻塞性冠状动脉(MINOCA)的潜在病因。
尽管甲状腺功能亢进导致的MINOCA在年轻孕妇中是罕见的发现,但由于适当和特定的治疗可提高生存率,认识到这一病因至关重要。