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水痘引发的挑战:一例老年患者的呼吸道并发症病例

Varicella challenges: A case of respiratory tract complications in an elderly patient.

作者信息

Rahmi Alfina M, Prakasita Karine A, Damayanti Damayanti

机构信息

Department of Dermatology Venereology and Aesthetic, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Department of Dermatology Venereology and Aesthetic, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

出版信息

Narra J. 2024 Dec;4(3):e1150. doi: 10.52225/narra.v4i3.1150. Epub 2024 Nov 1.

Abstract

Varicella, caused by the varicella-zoster virus (VZV), is rarely reported in the elderly but often complicates with pneumonia. In this case report, we present a case of varicella pneumonia in the elderly. A 60-year-old man presented to the emergency room with vesicles filled with clear fluid that had appeared all over the body for the past four days. The patient also reported fever, headache, pain when swallowing, and itching. Initially, the rash consisted of pink macules that progressed to papules, vesicles, pustules, and crusts. The patient experienced a cough and shortness of breath one day before the hospital visit but did not report any chest or abdominal pain. Notably, the patient's two grandchildren had a history of chickenpox. The patient had been living with diabetes for five years and was undergoing treatment with insulin injections. The patient was also an active smoker for 40 years. On physical examination, several vesicles with varying degrees of redness were observed, along with yellow-black crusts, pustules, and erosions. Diagnostic tests revealed multinucleated giant cells on a Tzanck smear; pulmonary inflammation with thickening of the right hilum on a chest X-ray; extended-spectrum beta-lactamases in the sputum culture; and elevated hemoglobin A1c, blood sugar level, and liver and kidney function markers on laboratory examination. Based on the clinical findings, the patient was diagnosed with varicella, community-acquired pneumonia, diabetes, acute renal failure, and elevated transaminase enzymes. The patient was treated with acyclovir, paracetamol, salicylate 2% powder, fusidic acid 2% cream, moxifloxacin, N-acetylcysteine, curcuma, and insulin. The patient's clinical condition improved, the complaint of dyspnea decreased, and the patient was discharged to outpatient care after eight days of hospitalization. This case highlights that while varicella is rare in the elderly, it often presents with severe varicella pneumonia, making early detection and comprehensive management essential to prevent complications and mortality.

摘要

水痘由水痘-带状疱疹病毒(VZV)引起,在老年人中很少见,但常并发肺炎。在本病例报告中,我们呈现了一例老年水痘肺炎病例。一名60岁男性因过去四天全身出现充满清亮液体的水疱而到急诊室就诊。患者还报告有发热、头痛、吞咽时疼痛和瘙痒。最初,皮疹由粉红色斑疹组成,随后发展为丘疹、水疱、脓疱和结痂。患者在就诊前一天出现咳嗽和呼吸急促,但未报告任何胸痛或腹痛。值得注意的是,患者的两个孙子有水痘病史。患者患有糖尿病五年,一直在接受胰岛素注射治疗。患者也是一名有40年烟龄的吸烟者。体格检查发现有几个不同程度发红的水疱,伴有黄黑色结痂、脓疱和糜烂。诊断检查显示Tzanck涂片有多核巨细胞;胸部X线显示右肺门增粗的肺部炎症;痰培养中有超广谱β-内酰胺酶;实验室检查显示糖化血红蛋白、血糖水平以及肝肾功能指标升高。根据临床 findings,患者被诊断为水痘、社区获得性肺炎、糖尿病、急性肾衰竭和转氨酶升高。患者接受了阿昔洛韦、对乙酰氨基酚、2%水杨酸粉、2%夫西地酸乳膏、莫西沙星、N-乙酰半胱氨酸、姜黄和胰岛素治疗。患者的临床状况有所改善,呼吸困难的主诉减轻,住院八天后出院接受门诊护理。本病例强调,虽然水痘在老年人中罕见,但常表现为严重的水痘肺炎,因此早期发现和综合管理对于预防并发症和死亡至关重要。 (注:原文中“Based on the clinical findings”这里的“findings”翻译为“发现”不太准确,结合语境可能是“依据临床表现”等意思,但按照要求未添加解释,直接保留英文。)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4e3/11734115/b8406c4d3192/NarraJ-4-e1150-g001.jpg

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