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转移性腺泡细胞肺癌多学科治疗方法的见解:当今罗马尼亚病理学家的作用。

Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist's Role in Romania Today.

作者信息

Lazureanu Dorela-Codruta, Burlea Amelia, Barna Robert, Cipu Daniela, Pasca Fenesan Mihaela, Icma Ioan, Cornianu Marioara

机构信息

Microscopic Morphology Department-Anatomical Pathology, ANAPATMOL Research Center, "Victor Babes" University of Medicine and Pharmacy, 300041 Timișoara, Romania.

Pathology Department, "Pius Brinzeu" Emergency County Clinical Hospital Timisoara, 300723 Timisoara, Romania.

出版信息

Curr Oncol. 2025 Jan 13;32(1):37. doi: 10.3390/curroncol32010037.

Abstract

: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass. It is histologically similar to this kind of tumor described in salivary glands, but with a different immunophenotype. In general, it poses a reduced degree of malignancy, with indolent growth and a favorable prognosis, with exceptionally rare cases associated with recurring disease or lymph node metastases. : When clinicians are facing puzzling symptomatology in their patients, the main role of the multidisciplinary team in their review of oncological cases is to recommend imagistic-guided biopsies. Tissues samples were routinely processed, stained with hematoxylin-eosin (HE) and periodic acid-Schiff (PAS), and submitted to complementary immunohistochemistry tests. : Histopathological reports were consistent for lung ACC with regional lymph node involvement and remote metastases. Oncological therapies followed. : Postponements of the presentation to the doctor at the onset of symptoms, as well as a lack of periodic health control for people insured by national health insurance companies, often lead to medical, human and financial complications that are difficult to manage. The pathologist involved in the discussion of oncological cases brings his expertise in solving cases, certifying the evolution of tumors considered less aggressive, such as in the case of lung ACCs.

摘要

腺泡细胞癌(ACC)是一种罕见的肺部肿瘤,可作为实质性或支气管内肿块影响儿童和成人。其组织学特征与唾液腺中描述的此类肿瘤相似,但免疫表型不同。一般来说,它的恶性程度较低,生长缓慢,预后良好,仅有极少数病例会出现疾病复发或淋巴结转移。

当临床医生面对患者令人困惑的症状时,多学科团队在肿瘤病例评估中的主要作用是推荐影像引导下的活检。组织样本常规处理,用苏木精-伊红(HE)和过碘酸-希夫(PAS)染色,并进行补充免疫组化检测。

组织病理学报告显示肺ACC伴有区域淋巴结受累和远处转移。随后进行了肿瘤治疗。

症状出现时推迟就医,以及国家健康保险公司参保人员缺乏定期健康检查,往往会导致难以处理的医疗、人力和财务并发症。参与肿瘤病例讨论的病理学家凭借其专业知识解决病例,证实被认为侵袭性较小的肿瘤的进展情况,如肺ACC病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ee/11763930/c31eb583c167/curroncol-32-00037-g001.jpg

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