Thomas Maya Natasha, Skopiński Piotr, Roberts Harry, Woronkowicz Małgorzata
NDDH, Royal Devon University Healthcare NHS Foundation Trust, Barnstaple EX31 4JB, UK.
Department of Ophthalmology, SPKSO Ophthalmic University Hospital, Medical University of Warsaw, 00-576 Warsaw, Poland.
Int J Mol Sci. 2025 Jan 10;26(2):532. doi: 10.3390/ijms26020532.
Pseudoexfoliation syndrome (PXS) is an age-related fibrillopathy where fibrillar exfoliation material accumulates and deposits in ocular and extra-ocular tissue. Within the eye, this substance accumulates on the ocular surface and in the anterior segment of the eye, impacting ocular structures such as the conjunctiva, Tenon's capsule, sclera, cornea, iris, ciliary body, trabecular meshwork, and lens. This review aims to collate the current literature on how each anatomical part of the eye is affected by PXS, with a strong focus on molecular changes. We also summarise the current understanding of the key genetic factors influencing the development of PXS.
假性剥脱综合征（PXS）是一种与年龄相关的纤维病变，其中纤维状剥脱物质在眼内和眼外组织中积聚并沉积。在眼内，这种物质积聚在眼表和眼前节，影响结膜、Tenon囊、巩膜、角膜、虹膜、睫状体、小梁网和晶状体等眼部结构。本综述旨在整理当前关于眼睛各解剖部位如何受PXS影响的文献，重点关注分子变化。我们还总结了目前对影响PXS发生发展的关键遗传因素的理解。
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