雄激素化雌性大鼠发育过程中的下丘脑脱氧核糖核酸酶与DNA含量
Hypothalamic deoxyribonucleases and DNA content during development of the androgenized female rat.
作者信息
Litteria M
出版信息
Brain Res. 1985 Feb;350(1-2):297-300. doi: 10.1016/0165-3806(85)90273-1.
PMID:3986620
Abstract
The DNA content and activity of acid and alkaline deoxyribonucleases (DNases) were measured through age 60 days in the hypothalamus of female rats injected s.c. with 1.25 mg testosterone propionate 48 h after birth. DNA significantly increases through age 60 days, however, androgenization does not affect the DNases or DNA content. It is suggested that masculinization of the female hypothalamus does not involve alterations in net DNA synthesis and/or degradation.
摘要
在出生后48小时皮下注射1.25毫克丙酸睾酮的雌性大鼠下丘脑，测量其60日龄前的DNA含量以及酸性和碱性脱氧核糖核酸酶（DNase）的活性。DNA含量在60日龄前显著增加，然而，雄激素化并不影响DNase或DNA含量。这表明雌性下丘脑的雄性化并不涉及净DNA合成和/或降解的改变。
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