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2
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis.一项多中心、随机、双盲、安慰剂对照临床试验，评估磷虾油、虾青素和口服透明质酸复合物对轻度骨关节炎人群关节健康的疗效和安全性。
Nutrients. 2023 Aug 29;15(17):3769. doi: 10.3390/nu15173769.
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J Clin Med. 2023 Mar 18;12(6):2359. doi: 10.3390/jcm12062359.
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口服透明质酸治疗骨关节炎和腰痛：一项系统评价

Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review.

作者信息

de Carvalho Jozélio Freire, Davidson Josy

机构信息

Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEC), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.

Centro Universitário São Camilo, São Paulo-SP, Brazil.

出版信息

Mediterr J Rheumatol. 2024 Dec 31;35(4):557-562. doi: 10.31138/mjr.240724.oha. eCollection 2024 Dec.

DOI:10.31138/mjr.240724.oha
PMID:39886281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11778613/
Abstract

BACKGROUND

Hyaluronic acid (HA) has been largely used in clinical practice for rheumatic diseases. However, the effects of oral HA on these diseases are poorly understood.

AIM

To review articles evaluating oral HA's effects on rheumatic patients.

METHODS

PubMed was searched for articles on oral HA and rheumatic diseases between 1966 and May 2024.

RESULTS

Eleven articles were found with 597 patients. The diseases investigated were OA (n=10) and low back pain (n=1). Age varied from 40 to 70 years old, and female gender ranged from 43% to 75%. Follow-up ranged from 4 weeks to 12 months. The oral HA dosage varied from 30 mg to 300 mg/day. Concerning outcome, 9/11 articles observed improvement in rheumatic diseases in the following parameters: VAS pain, WOMAC, joint function, SF-36, Lequesne index, and stiffness. Two studies evaluated cytokines and observed a reduction of them after oral HA therapy. Adverse effects were rare and mild.

CONCLUSION

Oral HA seems to be a safe and effective therapy for OA and low back pain patients, although more studies should be done on the latter condition.

摘要

背景

透明质酸（HA）已广泛应用于风湿性疾病的临床实践。然而，口服HA对这些疾病的影响尚不清楚。

目的

综述评估口服HA对风湿性疾病患者影响的文章。

方法

在PubMed上检索1966年至2024年5月期间关于口服HA和风湿性疾病的文章。

结果

共找到11篇文章，涉及597例患者。所研究的疾病为骨关节炎（n = 10）和腰痛（n = 1）。年龄在40至70岁之间，女性比例在43%至75%之间。随访时间从4周到12个月不等。口服HA的剂量从每天30毫克到300毫克不等。关于结果，9/11的文章观察到风湿性疾病在以下参数上有所改善：视觉模拟评分法（VAS）疼痛、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）、关节功能、简明健康状况调查量表（SF - 36）、勒奎恩指数和僵硬程度。两项研究评估了细胞因子，观察到口服HA治疗后细胞因子减少。不良反应罕见且轻微。

结论

口服HA似乎是治疗骨关节炎和腰痛患者的一种安全有效的疗法，尽管对于后者还需要更多的研究。