磺酰亚胺：药物设计中未被充分探索的生物电子等排体？
Sulfilimines: An Underexplored Bioisostere for Drug Design?
作者信息
Arvidsson Per I
机构信息
Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden.
Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban 4001, South Africa.
出版信息
J Med Chem. 2025 Feb 27;68(4):4056-4058. doi: 10.1021/acs.jmedchem.5c00195. Epub 2025 Jan 31.
Sulfilimines have so far received little attention as a bioisostere for sulfoxides in the design of biologically active compounds. A recent study on physicochemical and in vitro drug-like properties shows that sulfilimines deserve a place in the medicinal chemist's toolbox.
到目前为止，在生物活性化合物设计中，亚磺酰亚胺作为亚砜的生物电子等排体几乎没有受到关注。最近一项关于物理化学和体外类药性质的研究表明，亚磺酰亚胺在药物化学家的工具库中值得占有一席之地。
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