Zhang Deju, Yuan Ying, Zeng Qingdong, Xiong Juan, Gan Yiming, Jiang Kai, Xie Ni
Biobank, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Front Pharmacol. 2025 Jan 17;15:1468977. doi: 10.3389/fphar.2024.1468977. eCollection 2024.
Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women's health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate breast cancer progression. PDBP are natural, non-toxic, and affordable substances and have demonstrated excellent anti-breast cancer activities in inhibiting proliferation, migration, and invasion, and promoting apoptosis both and , thus effectively preventing or inhibiting breast cancer. However, there are no comprehensive reviews summarizing the effects and mechanisms of PDBP on the treatment of breast cancer. Therefore, this review described the inhibitory effects and mechanisms of active peptides from different plant protein sources on breast cancer. Additionally, we summarized the advantages and preparation methods of plant protein-derived anticancer peptide-encapsulated nanoparticles and their effects in inhibiting breast cancer. This review provides a scientific basis for understanding the anti-breast cancer mechanisms of PDBP and offers guidance for the development of therapeutic adjuvants enriched with these peptides.
乳腺癌每年导致约68.5万名女性死亡，对女性健康构成严重威胁。因此，迫切需要低成本、低毒性且有效的治疗方法来预防或减轻乳腺癌的进展。植物源生物活性肽（PDBP）是天然、无毒且价格低廉的物质，在抑制增殖、迁移和侵袭以及促进凋亡方面均表现出优异的抗乳腺癌活性，从而有效预防或抑制乳腺癌。然而，目前尚无全面综述总结PDBP对乳腺癌治疗的作用及机制。因此，本综述阐述了不同植物蛋白来源的活性肽对乳腺癌的抑制作用及机制。此外，我们总结了植物蛋白衍生抗癌肽包封纳米粒的优势、制备方法及其在抑制乳腺癌方面的作用。本综述为理解PDBP的抗乳腺癌机制提供了科学依据，并为富含这些肽的治疗佐剂的开发提供了指导。
