Amano Yoshifumi, Koizumi Kohei, Takizawa Hirokazu, Tasaka Shota, Hamaguchi Toyohiro
Narimasu Kousei Hospital, Itabashi Ward, Tokyo, Japan.
Department of Rehabilitation, Graduate School of Health Science, Saitama Prefectural University, Koshigaya City, Saitama Prefecture, Japan.
Neuropsychopharmacol Rep. 2025 Mar;45(1):e70002. doi: 10.1002/npr2.70002.
Alcohol use disorder (AUD) is characterized by severe dependence on alcohol, poor impulse control, and heightened attention to alcohol-related cues. Attention bias modification (ABM) retrains individuals to distract attention from alcohol-related cues. This study investigates the effect of combining ABM with cognitive behavioral therapy (CBT) to reduce relapse risk and cravings in male patients with AUD.
A quasi-randomized controlled trial was conducted among male inpatients diagnosed with AUD. Participants were divided into an intervention group receiving ABM in addition to CBT and a control group receiving CBT with a placebo intervention. The primary outcomes-risk of relapse and craving levels-were measured using the Alcohol Relapse Risk Scale (ARRS) and a visual analog scale (VAS), respectively. Participants underwent weekly sessions over 6 weeks, and outcomes were analyzed using generalized linear models (GLMs).
The analysis did not reveal significant interactions between the intervention group and time for ARRS scores and craving levels. Both groups experienced a reduction in relapse risk and cravings. However, there was no significant difference between the ABM + CBT and CBT-only groups.
Although the combined ABM and CBT intervention did not result in statistically significant reductions in relapse risk and cravings compared to CBT alone, the overall reduction in these outcomes in both groups highlights the effectiveness of CBT in treating AUD. Future studies should use naturalistic settings and tailor the intervention to individual cognitive profiles.
酒精使用障碍(AUD)的特征是对酒精严重依赖、冲动控制能力差以及对与酒精相关线索的关注度增加。注意力偏差修正(ABM)可重新训练个体将注意力从与酒精相关的线索上转移开。本研究调查将ABM与认知行为疗法(CBT)相结合对降低男性AUD患者复发风险和渴望程度的效果。
对诊断为AUD的男性住院患者进行了一项半随机对照试验。参与者被分为干预组(除接受CBT外还接受ABM)和对照组(接受CBT及安慰剂干预)。主要结局——复发风险和渴望程度——分别使用酒精复发风险量表(ARRS)和视觉模拟量表(VAS)进行测量。参与者在6周内每周接受一次治疗,并使用广义线性模型(GLM)对结局进行分析。
分析未发现干预组与时间在ARRS评分和渴望程度方面存在显著交互作用。两组的复发风险和渴望程度均有所降低。然而,ABM+CBT组与仅接受CBT组之间没有显著差异。
尽管与单独使用CBT相比,ABM与CBT联合干预在复发风险和渴望程度方面并未导致具有统计学意义的降低,但两组这些结局的总体降低突出了CBT在治疗AUD方面的有效性。未来的研究应采用自然环境,并根据个体认知特征调整干预措施。