Lan Qianyu, Liu Shasha, He Qianqian, Li Yuan
Department of General Internal Medicine, The Fourth Hospital of Shijiazhuang, No. 16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
The Fifth Department of Obstetrics and Gynecology, The Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Arch Gynecol Obstet. 2025 Mar;311(3):731-740. doi: 10.1007/s00404-025-07941-8. Epub 2025 Feb 5.
Echo-tracking (ET) technology can visually determine whether vascular endothelial function is impaired. However, it remains uncertain whether routine ET testing for pregnant women could effectively diagnose pregnancy concurrent with hypertension (PCH) based on changes in vascular elasticity.
An ET ultrasound system was employed to assess the elasticity of the carotid artery. The plasma nitric oxide (NO) levels were determined using radioimmunoassay, and the levels of endothelin-1 (ET-1) were determined using an enzyme-linked immunosorbent assay. The prediction of PCH occurrence was assessed using receiver-operating characteristic curve analysis. The correlation between the two factors was evaluated using regression analysis.
Pregnant women with PCH display significant differences in systolic blood pressure, diastolic blood pressure, and proteinuria compared to those with normal pregnancies. ET parameters, such as pulse wave velocity β (PWVβ), β-stiffness, pressure-strain elastic modulus (Eρ), and arterial compliance (AC), also reveal significant variances between women with PCH and those with normal pregnancies. These four factors are strongly associated with the disease progression in women with PCH and serve as reliable predictors for the occurrence of PCH. Additionally, the ET-1 level increases, while the NO level decreases in women with PCH, having the ability to predict the occurrence of PCH. Carotid endothelial elasticity decreases, and carotid endothelial function is impaired in pregnant women with PCH.
The ET parameters and indexes of carotid endothelial function can reliably predict the occurrence of PCH.
回声跟踪（ET）技术可直观判断血管内皮功能是否受损。然而，基于血管弹性变化，对孕妇进行常规ET检测能否有效诊断妊娠合并高血压（PCH）仍不确定。
采用ET超声系统评估颈动脉弹性。采用放射免疫分析法测定血浆一氧化氮（NO）水平，采用酶联免疫吸附测定法测定内皮素-1（ET-1）水平。采用受试者工作特征曲线分析评估PCH发生的预测情况。采用回归分析评估两个因素之间的相关性。
与正常妊娠孕妇相比，PCH孕妇在收缩压、舒张压和蛋白尿方面存在显著差异。ET参数，如脉搏波速度β（PWVβ）、β硬度、压力应变弹性模量（Eρ）和动脉顺应性（AC），在PCH孕妇和正常妊娠孕妇之间也显示出显著差异。这四个因素与PCH孕妇的疾病进展密切相关，是PCH发生的可靠预测指标。此外，PCH孕妇的ET-1水平升高，而NO水平降低，具有预测PCH发生的能力。PCH孕妇的颈动脉内皮弹性降低，颈动脉内皮功能受损。
ET参数和颈动脉内皮功能指标可可靠预测PCH的发生。
