高尔基体恢复的囊泡补充延缓骨骼衰老并增强衰老骨骼的再生能力。
Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration.
作者信息
Liu Peisheng, Guo Hao, Huang Xiaoyao, Liu Anqi, Zhu Ting, Zheng Chenxi, Fu Fei, Zhang Kaichao, Li Shijie, Luo Xinyan, Tian Jiongyi, Jin Yan, Xuan Kun, Sui Bingdong
机构信息
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
出版信息
Bone Res. 2025 Feb 8;13(1):21. doi: 10.1038/s41413-024-00386-w.
Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration. Interestingly, replenishment of cell aggregates-derived extracellular vesicles (CA-EVs) rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5. Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. Collectively, our findings provide insights into Golgi regulation in stem cell senescence and bone aging, which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.
健康老龄化是人类和社会的共同目标，实现这一目标的关键之一是使衰老的驻留干细胞恢复活力并增强衰老器官的再生能力。然而，对干细胞衰老的机制理解以及对抗它的潜在策略仍然难以捉摸。在这里，我们揭示衰老的骨微环境会损害高尔基体，从而削弱间充质干细胞（MSC）的功能和再生能力。有趣的是，补充细胞聚集体衍生的细胞外囊泡（CA-EV）可挽救高尔基体功能障碍，并通过高尔基体调节蛋白Syntaxin 5增强衰老的间充质干细胞的功能。重要的是，在衰老小鼠体内施用CA-EV可显著提高骨缺损修复率并改善骨量，表明它们在治疗与年龄相关的骨质疏松症和促进骨再生方面具有治疗价值。总体而言，我们的研究结果为干细胞衰老和骨衰老中的高尔基体调节提供了见解，这进一步突出了CA-EV作为衰老骨再生的潜在恢复活力方法。
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